A novel cuproptosis-related immune checkpoint gene signature identification and experimental validation in hepatocellular carcinoma
As current staging systems for cancer are typically found through anatomical evaluations of the disease, stratification of patients for treatment and further therapy strategies prove difficult. Much potential remains in cancer biomarker research for the identification of prognostic gene expression signatures capable of classifying tumor subgroups via their biological counterparts. With the advancements in genomic and transcriptomic technologies, researchers are making great discoveries in cancer biomarkers for detection, prediction of therapeutic response and prognoses of cancer. Recent research highlights a new cuproptosis (copper-induced death) related immune checkpoint gene signature recently investigated as a potential biomarker for anticancer therapy for hepatocellular carcinoma.
Cancer-seeking molecular delivery system could boost immunotherapy drug, research finds
For past decades, the treatment of cancer has generally meant surgery, radiation, chemotherapy, or a combination of the above. Through recent work from a collaboration of researchers from the University of Rhode Island and Yale University comes the promising new approach of delivering immunotherapy agents, STING agonists, via a cancer-seeking molecular delivery system. The delivery relies on the acid-seeking molecule- pHLIP. These molecules deliver cargo directly to the tumor environment via targeting of the high acidity of cancerous tumors. Through this novel drug delivery technique, cancer immunotherapy may become even more effective.Continue reading
Putin weaponizing refugees: NATO must draw red lines and enforce them
WMD in Ukraine: a planetary near-death experience
Op-Ed in the Hill written by Drs’ Helfand, Callahan, Hodgkin and Poznansky on the continued existence of weapons of mass destruction and the unacceptable threat to the Ukraine, global security and public health.
“The war in Ukraine is now in its fifth month and, while the brutal toll of military and civilian casualties continues to climb, the territorial lines have become increasingly static, with mostly incremental gains by Russian forces in Ukraine’s eastern Donbas region. We continue to learn of human rights violations, from intentional targeting of civilians and civilian infrastructure to deportation of Ukrainian civilians into Russia. Despite the devastation…”
The Harvard Gazette – Viewing Ukraine’s war-torn health care through a personal lens
Physicians Polina Teslyar, Nelya Melnitchouk, Mark Poznansky, Serguei Melnitchouk, Dana Ronak and Rolin Kostya, and Gennadiy Fuzaylov speak with Harvard-affiliated doctors from Brigham and Women’s and MGH via Zoom to discuss the situation in Ukraine.
“Both Serguei Melnitchouk and his wife, Nelya, are surgeons, he at Massachusetts General Hospital and she at Brigham and Women’s Hospital. Both are Harvard Medical School assistant professors, and both have families who are safe for now in small towns in Ukraine.
“We are constantly checking the news and trying to find ways to help,” said Nelya, who directs the Brigham’s colorectal surgery fellowship and is working with her husband on a series of medical aid projects for Ukraine. “Obviously, this whole war is very close to my heart.”
Dr. Gennadiy Fuzaylov from HUG and through his organization, DCHC, has successfully assisted transporting afflicted children from the Ukraine to hospitals in the US.
Boston burn doctors help save suffering Ukrainian children
“Two young children with severe burns, accompanied by a single parent each, fled by car from different regions of war-ravaged Ukraine toward the Polish border. From Poland, away from Russian bombs, they boarded a flight that is at least 10 hours long no matter if they flew from border cities like Lublin or Rzeszow or from the capital Warsaw, and landed sometime around midnight — late Wednesday or early Thursday — to be treated by burn specialists at Boston’s…”