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Gelfand LAB

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Mission Statement:

To apply evolving knowledge of immunology, pharmacology, and light- based mechanisms to create novel therapeutic approaches for immune, cancer, and infectious diseases.

Research Focus:

Create devices and therapeutics to address longstanding clinical deficiencies and therapeutic needs

VIC Projects List

  • Development of clinically adaptable devices employing light based therapy and light-based enhancement of antimicrobial substances to highly resistant wound organisms and chronic infections.
  • Development of laser adjuvant approaches to the enhancement of intradermal vaccines for infectious diseases and cancers.
  • Development of a self- assembling vaccine for the rapid creation of peptide based vaccines for infectious diseases as well as the development of personalized cancer vaccines to guide the immunotherapy of cancers.
  • Development of heat shock protein based antibody fusion for the immunotherapy of cancer.

Highlighted Publications

Antimicrobial Photodynamic Inactivation Mediated by Tetracyclines in Vitro and in Vivo: Photochemical Mechanisms and Potentiation by Potassium Iodide

Sci Rep. 2018; 8: 17130. Published online 2018 Nov 20. doi: 10.1038/s41598-018-35594-y PMCID: PMC6244358 Weijun Xuan, Ya He, Liyi Huang, Ying-Ying Huang, Brijesh Bhayana, Liyan Xi, Jeffrey A. Gelfand, Michael R. Hamblin.

Antimicrobial photodynamic therapy mediated by methylene blue and potassium iodide to treat urinary tract infection in a female rat model

Sci Rep. 2018 May 8;8(1):7257. doi: 10.1038/s41598-018-25365-0. PMID: 29740035 (*co-equal first authors)
Huang YY, Wintner A, Seed PC, Brauns TA, Hamblin MR*, Gelfand JA*.

Tetracyclines function as dual-action light-activated antibiotics.

PLoS One. 2018 May 9;13(5):e0196485. doi: 10.1371/journal.pone.0196485. PMID: 29742128 (*co-equal first authors)
He Y, Huang YY, Liyan X, Gelfand JA*, Hamblin MR*. Tetracyclines function as dual-action light-activated antibiotics.

A pilot clinical trial of a near-infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking.

FASEB J. 2019 Feb;33(2):3074-3081. doi: 10.1096/fj.201801095R. PMID: 30192655
Gelfand J, Nazarian R, Kashiwagi S, Brauns T, Martin B, Kimizuka Y, Botvinick E, Elkins K, Thomas L, Locascio J, Parry B, Kelly KM, Poznansky M

Improved antitumoral efficacy of mesothelin targeted immune activating fusion protein in murine model of ovarian cancer.

Int J Cancer Clin Res 2016, 3:051-55.
Zeng Y, Li B, Reeves P, Ran R, Zhao Liu, Agha-Abbaslou M, Yuan J, Leblanc P, Sluder A, Gelfand J, Brauns T, Poznansky M, Chen H.
View Full List of Lab Publications VIA PUBMED

RESEARCH TEAM

Jeffrey A Gelfand, MD

Principal Investigator

Laisa Bonafim Negri, Ph.D.

Research Fellow

Yara Mannaa, B.A.

Research Assistant
ALUMNI