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Gelfand LAB

Mission Statement:

To apply evolving knowledge of immunology, pharmacology, and light- based mechanisms to create novel therapeutic approaches for immune, cancer, and infectious diseases.

Research Focus:

Create devices and therapeutics to address longstanding clinical deficiencies and therapeutic needs

VIC Projects List

Highlighted Publications

An antimicrobial blue light device reduces bacterial bioburden in heavily contaminated wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) in a proof-of-concept, preclinical porcine model.

Laisa Bonafim Negri1,2,3,4, William Farinelli1,3, Sandeep Korupolu1,3, Ying Wang1,3, Yara Mannaa1,2,3, Hang Lee3,4, Jie Hui1,2,3,4, Pu-Ting Dong5, Joshua Tam 1,3,4, R. Rox Anderson1,3,4, Seok-Hyun Andy Yun1,3,4, Jeffrey A. Gelfand1

Vitamin K3 (Menadione) is a Multifunctional Microbicide acting as a Photosensitizer and Synergizing with Blue Light to Kill Drug-Resistant Bacteria in Biofilms.

Journal of Photochemistry and Photobiology B: Biology. 2023 May;244:112720.
Negri LB, Mannaa Y, Korupolu S, Farinelli WA, Anderson RR, Gelfand JA.

Photoinactivation of Moraxella Catarrhalis Using 405-nm Blue Light: Implications for the Treatment of Otitis Media.

Photochem Photobiol. 2020 May; 96(3):611-617. PMID: 32105346.
Liu X, Chang Q, Ferrer-Espada R, Leanse LG, Goh XS, Wang X, Gelfand JA, Dai T

A Pilot Clinical Trial of a Near–Infrared Laser Vaccine Adjuvant: Safety, Tolerability, and Cutaneous Immune Cell Trafficking.

FASEB J. 2019 Feb;33(2):3074-3081. Doi: 10.1096/fj.201801095R. PMID: 30192655
Gelfand JA, Nazarian R, Kashiwagi S, Brauns T, Martin B, Kimizuka Y, Botvinick E , Elkins K,   Thomas L, Locascio J, Parry B, Kelly KM, Poznansky MC.

Antimicrobial Photodynamic Therapy Mediated By Methylene Blue And Potassium Iodide To Treat Urinary Tract Infection In A Female Rat Model.

Sci Rep. 2018 May 8;8(1):7257. doi: 10.1038/s41598-018-25365-0. PMID: 29740035 Huang YY, Wintner A, Seed PC, Brauns TA, Hamblin MR, Gelfand JA. 

Tetracyclines Function As Dual-Action Light-Activated Antibiotics.

PLoS One. 2018 May 9;13(5):e0196485. doi: 10.1371/journal.pone.0196485. PMID: 29742128
He Y, Huang YY, Liyan X, Gelfand JA*, Hamblin MR*. Tetracyclines function as dual-action light-activated antibiotics.

Antimicrobial Photodynamic Inactivation Mediated By Tetracyclines In Vitro And In Vivo: Photochemical Mechanisms And Potentiation By Potassium Iodide.

Sci Rep. 2018 Nov 20.;8:17130. doi: 10.1038/s41598-018-35594-y PMCID: PMC6244358 Weijun Xuan, Ya He, Liyi Huang, Ying-Ying Huang, Brijesh Bhayana, Liyan Xi, Jeffrey A. Gelfand, Michael R. Hamblin.

A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection.

J Infect Dis. 2019 July 31; 220(5):873-881. PMID: 30629196; PMCID: PMC6667797.
Wang Y, Ferrer-Espada R, Baglo Y, Goh XS, Held KDGrad YH, Gu Y, Gelfand JA, Dai T

Clinical sensitivity and Interpretation of PCR and Serological COVID-19 Diagnostics for Patients Presenting to the Hospital.

FASEB J. 2020 10; 34(10):13877-13884. PMID: 32856766; PMCID: PMC7461169.


Jeffrey A Gelfand, MD

Principal Investigator

Laisa Bonafim Negri, Ph.D.

Research Fellow

Timothy Brauns, MBA

Technology Development Advisor



2021 Yara Mannaa, BA, Boston University


Help us to advance now the medicines of the future.