Gelfand LAB
Mission Statement:
Research Focus:
VIC Projects List
- Development of clinically adaptable devices employing light based therapy and light-based enhancement of antimicrobial substances to highly resistant wound organisms and chronic infections.
- Development of laser adjuvant approaches to the enhancement of intradermal vaccines for infectious diseases and cancers.
- Development of a self- assembling vaccine for the rapid creation of peptide-based vaccines for infectious diseases as well as the development of personalized cancer vaccines to guide the immunotherapy of cancers.
- Development of heat shock protein based antibody fusion for the immunotherapy of cancer.
- Development of approaches to using photon energy to augment antibiotic function.
Highlighted Publications
An antimicrobial blue light device reduces bacterial bioburden in heavily contaminated wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) in a proof-of-concept, preclinical porcine model.
Laisa Bonafim Negri1,2,3,4, William Farinelli1,3, Sandeep Korupolu1,3, Ying Wang1,3, Yara Mannaa1,2,3, Hang Lee3,4, Jie Hui1,2,3,4, Pu-Ting Dong5, Joshua Tam 1,3,4, R. Rox Anderson1,3,4, Seok-Hyun Andy Yun1,3,4, Jeffrey A. Gelfand1
Vitamin K3 (Menadione) is a Multifunctional Microbicide acting as a Photosensitizer and Synergizing with Blue Light to Kill Drug-Resistant Bacteria in Biofilms.
Journal of Photochemistry and Photobiology B: Biology. 2023 May;244:112720.
Negri LB, Mannaa Y, Korupolu S, Farinelli WA, Anderson RR, Gelfand JA.
Photoinactivation of Moraxella Catarrhalis Using 405-nm Blue Light: Implications for the Treatment of Otitis Media.
Photochem Photobiol. 2020 May; 96(3):611-617. PMID: 32105346.
Liu X, Chang Q, Ferrer-Espada R, Leanse LG, Goh XS, Wang X, Gelfand JA, Dai T.
A Pilot Clinical Trial of a Near–Infrared Laser Vaccine Adjuvant: Safety, Tolerability, and Cutaneous Immune Cell Trafficking.
FASEB J. 2019 Feb;33(2):3074-3081. Doi: 10.1096/fj.201801095R. PMID: 30192655
Gelfand JA, Nazarian R, Kashiwagi S, Brauns T, Martin B, Kimizuka Y, Botvinick E , Elkins K, Thomas L, Locascio J, Parry B, Kelly KM, Poznansky MC.
Antimicrobial Photodynamic Therapy Mediated By Methylene Blue And Potassium Iodide To Treat Urinary Tract Infection In A Female Rat Model.
Sci Rep. 2018 May 8;8(1):7257. doi: 10.1038/s41598-018-25365-0. PMID: 29740035 Huang YY, Wintner A, Seed PC, Brauns TA, Hamblin MR, Gelfand JA.
Tetracyclines Function As Dual-Action Light-Activated Antibiotics.
PLoS One. 2018 May 9;13(5):e0196485. doi: 10.1371/journal.pone.0196485. PMID: 29742128
He Y, Huang YY, Liyan X, Gelfand JA*, Hamblin MR*. Tetracyclines function as dual-action light-activated antibiotics.
Antimicrobial Photodynamic Inactivation Mediated By Tetracyclines In Vitro And In Vivo: Photochemical Mechanisms And Potentiation By Potassium Iodide.
Sci Rep. 2018 Nov 20.;8:17130. doi: 10.1038/s41598-018-35594-y PMCID: PMC6244358 Weijun Xuan, Ya He, Liyi Huang, Ying-Ying Huang, Brijesh Bhayana, Liyan Xi, Jeffrey A. Gelfand, Michael R. Hamblin.
A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection.
J Infect Dis. 2019 July 31; 220(5):873-881. PMID: 30629196; PMCID: PMC6667797.
Wang Y, Ferrer-Espada R, Baglo Y, Goh XS, Held KD, Grad YH, Gu Y, Gelfand JA, Dai T.
Clinical sensitivity and Interpretation of PCR and Serological COVID-19 Diagnostics for Patients Presenting to the Hospital.
RESEARCH TEAM
Jeffrey A Gelfand, MD
Laisa Bonafim Negri, Ph.D.
Timothy Brauns, MBA
2021 Yara Mannaa, BA, Boston University