Recent clinical trials at the University of Cincinnati are examining the effectiveness of a two-pronged immunotherapy procedure to treat glioblastomas, aggressive brain tumors. Current treatment involves the combination of surgery, radiation, and chemotherapy, as to ensure microscopic particles of cancerous tissue do not survive. But despite continued advancements over the past decade, patients with glioblastomas remain uncured. Current clinical trials utilize a two-pronged approach, administering a combination of two immunotherapy drugs in tandem, that target different immune checkpoint proteins to activate immune cells. Previous single immunotherapy treatment observed failure led to the two-pronged approach in current trials.