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High Dimensional Immunology

Research Summary

The mission of the HDI program is to conduct rigorous, highly detailed analysis of precious clinical and biological samples to promote our understanding of the immune system and advance the development of effective immune-based therapies.

Program Strategic Objectives:

The VIC HDI team has developed computational strategies and algorithms for analyzing high-dimensional data to identify specific immune system responses associated with clinical measures and outcomes. The program utilizes multiple high-parameter technologies, applying them singly or in combination as appropriate for a specific project to maximize the amount of information obtained from small clinical samples of blood or tissue, such as

Outputs from these assays, together with classical immunoassays and clinical data can be interrogated using a robust repertoire of computational and statistical tools to gain novel insights and identify actionable hallmarks.

The HDI program is open to collaboration with academic and industry researchers from outside of VIC and MGH.

Current active projects address a range of clinical areas, including:


Multi Parameter Histopathology


Patrick Reeves, PhD

Program Director

Mark Poznansky, MD, PhD

Center Director

Ann Sluder, PhD

Center Associate Director

Ruxandra Sîrbulescu, PhD

Principal Investigator

Nicholas Surguladze, BS

Lab Manager

Susan Raju Paul, MBBS

Research Associate

Richard Dzeng, MS

Research Technologist

David Verrill, MS

Research Technician

Divya Mirgh, BTech, MS

Research Technician

Allison Mitchell, MPH

Project Manager

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