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High Dimensional Immunology

Research Summary

The mission of the HDI program is to provide highly detailed analysis of biological samples to advance our understanding of the immune system through comprehensive profiling to inform mechanistic studies and facilitate the development of effective immune-based therapies.

The overall objectives of the program are:

The VIC HDI team has developed computational strategies and algorithms for analyzing high-dimensional data to identify specific immune system responses associated with clinical measures and outcomes. The program utilizes multiple high-parameter technologies, applying them singly or in combination as appropriate for a specific project to maximize the amount of information obtained from small clinical samples of blood or tissue, such as
Outputs from these assays, together with classical immunoassays and clinical data can be interrogated using a robust repertoire of computational and statistical tools to gain novel insights and identify actionable hallmarks. The HDI program is open to collaboration with academic and industry researchers from outside of VIC and MGH. Current active projects address a variety of clinical areas, including infectious disease vaccines, the immune microenvironment in solid tumors, immune system changes following organ transplantation or traumatic injury, and immune dysfunction in degenerative diseases.


Multi Parameter Histopathology


Mark Poznansky, MD, PhD

Center Director

Ann Sluder, PhD

Center Associate Director

Patrick Reeves, PhD

Principal Investigator

Ruxandra Sîrbulescu, PhD

Principal Investigator

David Gregory, PhD

Project Manager

Susan Raju Paul, MBBS

Research Associate

Richard Dzeng, MS

Research Technologist

David Verrill, MS

Research Technician

Emily Hill, BS

Research Technician

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