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High Dimensional Immunology

Research Summary

The VIC HDI program takes a holistic approach to understanding human inflammatory and immune responses through use of technologies enabling parallel assessment of multiple cellular and clinical parameters.

The overall objectives of the program are:

VIC HDI scientists have developed computational strategies and algorithms for analyzing high-dimensional data to identify specific immune system responses associated with clinical measures and outcomes. The program utilizes multiple high-parameter technologies, applying them singly or in combination as appropriate for a specific project to maximize the amount of information obtained from small clinical samples of blood or tissue, such as
The HDI program is open to collaboration with academic and industry researchers from outside of VIC and MGH. Current active projects address a variety of clinical areas, including infectious disease vaccines, the immune microenvironment in solid tumors, immune system changes following organ transplantation or traumatic injury, and immune dysfunction in degenerative diseases.


Multi Parameter Histopathology


Laura Valine, B. Sc.

HDI Cell Assay Technician

Joshua M. Hess, B. Sc.

HDI Data Analysis Technician

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