To enhance immunoprotection and support of transplanted allogeneic islets or human stem cell derived beta cells without systemic immune suppression and develop efficacious and safe novel therapies for targeted delivery of therapeutic cargo to the graft to treat and prevent type 1 diabetes (T1D).
The Dogan Laboratory is exploring the development and testing of microgels containing CXCL12 and FasL to enable allo-islet transplantation for T1D without systemic immune suppression. Dr. Dogan also aims to develop a novel, safe and effective islet-targeted gene delivery system to restore and enhance immune protection of the pancreatic islets.
- Combining different approaches to achieve enhanced immunoprotection and support of transplanted allogeneic islets without systemic immune suppression to cure T1D.
- Development of new strategies for targeted delivery of therapeutic cargo to the pancreatic islets.
- Using the state-of-art technologies to deliver an immunomodulatory gene, with the potential for translation to clinical trials and for economic large-scale application.
- Targeting the proinsulin processing pathway to prevent T1D.
- B cell immunotherapy for T1D: Approaches to reverse diabetes using B cell therapy in T1D mice model.
- Imaging Mass Cytometry (IMC): Development of a mouse immune profiling panel for IMC to monitor islet rejection in tissue sections.
Faseb BioAdvances 2023; 5: 287-304. doi:10.1096/fba.2023-0002900:1–18. Lu, K.; Brauns, T.; Sluder, A. E.; Poznansky, M. C.; Dogan F.
Cancers (Basel). 2021 Mar 10;13(6):1213. doi:10.3390/cancers13061213. PMID: 33802026; PMCID: PMC8000866. Dogan, F.; Forsyth, N.R.
Cells. 2021 Apr 27;10(5):1032. doi: 10.3390/cells10051032. PMID: 33925659; PMCID: PMC8145390. Dogan, F.; Aljumaily, R.M.K.; Kitchen, M.; Forsyth, N.R.
Int J Low Extrem Wounds. 2020 Mar 4:1534734620907773. doi:10.1177/1534734620907773. Epub ahead of print. PMID: 32131656. Çetinkalp Ş, Gökçe EH, Şimşir I, Tuncay Tanrıverdi S, Doğan F, Biray Avcı Ç, Eroğlu İ, Utku T, Gündüz C, Özer Ö.
J Cell Biochem. 2019 Jan;120(1):380-395. doi:10.1002/jcb.27393. Epub 2018 Aug 26. PMID: 30145828. Sogutlu F, Kayabasi C, Ozmen Yelken B, Asik A, Gasimli R, Dogan F, Yilmaz Süslüer S, Biray Avcı C, Gunduz C.
J Cell Biochem. 2018 Dec;119(12):9817-9824. doi:10.1002/jcb.27301. Epub 2018 Aug 26. PMID: 30145821. Biray Avci C, Dogan F, Ozates Ay NP, Goker Bagca B, Abbaszadeh Z, Gunduz C.
J Cell Biochem. 2019 Feb;120(2):1282-1293. doi: 10.1002/jcb.27089. Epub 2018 Oct 28. PMID: 30368861. Dogan, F., Ozates Ay NP, Goker Bagca B, Z. Abbaszadeh, Söğütlü F.,Gasımlı R., Gündüz C, Ç. B. Avcı, 2018
Gene. 2018 Jan 30;641:235-239. doi: 10.1016/j.gene.2017.09.072. Epub 2017 Oct 24. PMID: 29074462. Dogan, F. & Avci, C. B., 2017.
Ben Shaer, student of Gann Academy, Waltham
Jihra James, BS candidate, Langston University