REEVES LAB
Mission Statement:
Research Focus:
VIC Projects List
- Infectious Disease Vaccine Development, Modular vaccine platform for rapid response to emerging infections, Detailed immunophenotyping of murine and clinical samples following infection or vaccination, Current vaccine projects: Q fever, influenza
- Immune Modulation to Combat Cancer, Tumor immune evasion, Modular vaccine platform for tailored individual cancer vaccines, Combination therapies to improve anti-tumor responses, Repurposing FDA approved drugs to shorten time to clinic, Detailed and broad profiling of the immune system and tumors to inform treatment development
- High-Dimensional Imaging to Map Features of Disease and Therapy, Building detailed molecular maps of tumors and diseased tissues to identify signatures of disease state and treatment response by integrating multi-modal data from: Imaging mass cytometry: organization and functional status of cell populations within tissues,Mass spectrometry imaging: distribution of metabolites, lipids, proteins, and drugs, Standard H&E and immuno-labeling methods: established measures of pathology
Highlighted Publications
Selective Bcl-2 inhibition promotes hematopoietic chimerism and allograft tolerance without myelosuppression in nonhuman primates.
B cell-dependent subtypes and treatment-based immune correlates to survival in stage 3 and 4 lung adenocarcinomas.
Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes.
Cancer Cell. 2022 Aug 8;40(8):879-894.e16. doi: 10.1016/j.ccell.2022.07.006. PubMed PMID: 35944503. Zaitsev A, Chelushkin M, Dyikanov D, Cheremushkin I, Paul SR, Davies DL, Reeves PM, Hsieh JJ, Ramachandran A, Cerchietti L, Poznansky MC.
Oncotarget. 2017 Oct 4;8(55):94040-94053. doi: 10.18632/oncotarget.21541. eCollection PMID: 29212208
Reeves PM, Abbaslou MA, Kools FRW, Vutipongsatorn K, Tong X, Gavegnano C, Schinazi RF, Poznansky MC.
FASEB J. 2018 Jan;32(1):5-15. doi: 0.1096/fj.201700325R. Epub 2017 Nov 1. Review. PubMed PMID: 29092906.
Reeves PM, Sluder AE, Paul SR, Scholzen A, Kashiwagi S, Poznansky MC.
Research team
Stella Nam, MS Candidate
Divya Mirgh, BTech, MS
Sonia Mukherjee, MS
Richard Dzeng, MS
John Nam, BS, MRes, MD Candidate
Petra Bachanova, MS, PhD Student
Jacob Jennings Smith, PhD Candidate
2023 Nanna Sivamanoharan BSc, MSc, MD candidate at Edinburgh University
2018-2021 Josh M. Hess, B.Sc., Emory and Henry College
2021 Maia Pavlovic, B.Sc.
2020 Katarina Ho, B.Sc.
2020-2021 Morgan Friesen, MSC – Univ. of Utrecht (Netherlands)
2015-2019 Susan Raju Paul, MBBS
2017-2019 Yuexiong Yi, MD PhD – Surgeon Zhongnan Hospital
2018-2019 Shengdong Wang, MD – PhD student Zheijang University
2017-2019 Skylar Korek, B.Sc. MD/PhD student, Florida International University
2016-2017 Farah Kools, M.S. PhD Candidate, Utrecht University (Netherlands)
2016 Anita Vorha, B.Sc. Research Associate–Harvard Medical School
2016 Ellie Dunstone, B.Sc. PhD Candidate, Cambridge University (UK)
2016 Carl Pierce, B.Sc. MD/PhD Student, Albert Einstein Medical School
2015-2016 Ottavia Clemente, PhD Pharmaceutical Research Scientist
2015-2016 Xavier Catena, M.S. PhD Student, Spanish National Cancer Center
2015 Kritchai “Jay” Vutipongsatorn, B.Sc. MD Student, Imperial College, London
2015 Jan Orlewsky, M.D. Medical Resident
2014-2016 Mojgan Abbaslou, MD Medical Resident
2014 Samantha Wong, B.Sc. PhD Candidate, Harvard Medical School
John Nam, BS, MRes, MD Candidate, Research Technician