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REEVES LAB

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Mission Statement:

Detailed interrogation of the immune system to drive development of vaccines and therapeutic strategies in the context of infectious diseases, post-surgical care, and cancer.

Research Focus:

Work in the Reeves Laboratory investigates mechanisms governing the immune response to disease, with particular interest in intracellular pathogens, solid tumors, and immune dysregulation following surgery/trauma. Across projects, we apply deep-immune profiling and computational approaches to gain a more detailed understanding of the interface of the immune system with disease and the levers of effective immune-modulating therapies.

VIC Projects List

  • Infectious Disease Vaccine Development, Modular vaccine platform for rapid response to emerging infections, Detailed immunophenotyping of murine and clinical samples following infection or vaccination, Current vaccine projects: Q fever, influenza
  • Immune Modulation to Combat Cancer, Tumor immune evasion, Modular vaccine platform for tailored individual cancer vaccines, Combination therapies to improve anti-tumor responses, Repurposing FDA approved drugs to shorten time to clinic, Detailed and broad profiling of the immune system and tumors to inform treatment development
  • High-Dimensional Imaging to Map Features of Disease and Therapy, Building detailed molecular maps of tumors and diseased tissues to identify signatures of disease state and treatment response by integrating multi-modal data from: Imaging mass cytometry: organization and functional status of cell populations within tissues,Mass spectrometry imaging: distribution of metabolites, lipids, proteins, and drugs, Standard H&E and immuno-labeling methods: established measures of pathology

Highlighted Publications

Deep immune profiling of whole blood to identify early immune signatures that correlate to patient outcome after major trauma

J Trauma Acute Care Surg. 2021 Jun 1;90(6):959- 966. PMID: 33755643 Mendoza AE, Raju Paul S, El Hechi M, Naar L, Nederpelt C, Mikdad S, van Erp I, Hess JM, Velmahos GC, Poznansky M, Reeves P.

Polyfunctionality of the CXCR4/CXCL12 axis in health and disease: Implications for therapeutic interventions in cancer and immune-mediated diseases

FASEB J. 2021 Apr;35(4):e21260. doi: 10.1096/fj.202001273R. PMID: 33715207 Review. Britton C, Poznansky MC, Reeves P.

Novel multiparameter correlates of Coxiella burnetii infection and vaccination identified by longitudinal deep immune profiling

Sci Rep. 2020 Aug 7;10(1):13311. doi: 10.1038/s41598-020-69327-x. PMID: 32770104 Free PMC article. Reeves PM, Raju Paul S, Baeten L, Korek SE, Yi Y, Hess J, Sobell D, Scholzen A, Garritsen A, De Groot AS, Moise L, Brauns T, Bowen R, Sluder AE, Poznansky MC.

Rethinking the role of hydroxychloroquine in the treatment of COVID-19

FASEB J. 2020 May;34(5):6027-6037. doi: 10.1096/fj.202000919. Epub 2020 Apr 29. PMID: 32350928 Meyerowitz EA, Vannier AGL, Friesen MGN, Schoenfeld S, Gelfand JA, Callahan MV, Kim AY, Reeves PM, Poznansky MC.

Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice.

Oncotarget. 2017 Oct 4;8(55):94040-94053. doi: 10.18632/oncotarget.21541. eCollection PMID: 29212208
Reeves PM, Abbaslou MA, Kools FRW, Vutipongsatorn K, Tong X, Gavegnano C, Schinazi RF, Poznansky MC.

Application and utility of mass cytometry in vaccine development.

FASEB J. 2018 Jan;32(1):5-15. doi: 0.1096/fj.201700325R. Epub 2017 Nov 1. Review. PubMed PMID: 29092906.
Reeves PM, Sluder AE, Paul SR, Scholzen A, Kashiwagi S, Poznansky MC.

CXCR4 blockade with AMD3100 enhances Taxol chemotherapy to limit ovarian cancer cell growth.

Anticancer Drugs. 2017 Oct;28(9):935-942. doi: 10.1097/CAD.0000000000000518. PubMed PMID: 28817386. Reeves PM, Abbaslou MA, Kools FRW, Poznansky MC.

Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway.

Traffic 2016 Jan;17(1):40-52. doi: 10.1111/tra.12343. Epub 2015 Dec 9. PubMed PMID: 26481905 Reeves PM, Kang YL, Kirchhausen T.

View Full List of Lab Publications VIA PUBMED

Research team

Sonia Mukherjee, M.S.

Petra Bachanova, M.S.

Richard Dzeng, M.S.

Tyler Roady

Ella Gavin

 

 

2018-2021 Josh M. Hess, B.Sc., Emory and Henry College

2021 Maia Pavlovic, B.Sc.

2020 Katarina Ho, B.Sc.

2020-2021 Morgan Friesen, MSC – Univ. of Utrecht (Netherlands)

2015-2019 Susan Raju Paul, MBBS

2017-2019 Yuexiong Yi, MD PhD – Surgeon Zhongnan Hospital

2018-2019 Shengdong Wang, MD – PhD student Zheijang University

2017-2019 Skylar Korek, B.Sc. MD/PhD student, Florida International University

2016-2017 Farah Kools, M.S. PhD Candidate, Utrecht University (Netherlands)

2016 Anita Vorha, B.Sc. Research Associate–Harvard Medical School

2016 Ellie Dunstone, B.Sc. PhD Candidate, Cambridge University (UK)

2016 Carl Pierce, B.Sc. MD/PhD Student, Albert Einstein Medical School

2015-2016 Ottavia Clemente, PhD Pharmaceutical Research Scientist

2015-2016 Xavier Catena, M.S. PhD Student, Spanish National Cancer Center

2015 Kritchai “Jay” Vutipongsatorn, B.Sc. MD Student, Imperial College, London

2015 Jan Orlewsky, M.D. Medical Resident

2014-2016 Mojgan Abbaslou, MD Medical Resident

2014 Samantha Wong, B.Sc. PhD Candidate, Harvard Medical School

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