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Regenerative Medicine & Immunotherapy

Research Summary

At VIC, we aim to develop innovative strategies that harness key components of the immune system to address some of the most pressing challenges in diabetes (Alagpulinsa and Sîrbulescu Labs), neurotrauma, and neurodegenerative disease (Sîrbulescu Lab).

Preclinical studies in multiple model systems have yielded highly promising results.
Our team is in continuous active dialog with the Food and Drug Administration (FDA) regarding clinical testing of B cell immunotherapies, and in 2019-2020 we completed a first in human clinical study of B cell administration in a person with ALS. We have also initiated pilot preclinical studies with human stem cell- derived islets for type 1 diabetes treatment in non-human primates.

Currently, our main areas of focus are in:


Neurological Disorders

Regenerative medicine & immunotherapy pipeline

1 : Initial R&D

2 : Preclinical Efficacy

3 : Preclinical Safety

4 : Initial Human Studies

Highlighted Publications

Wound Repair Regen. 2017 Sep;25(5):774-791 PMID: 28922523
Sîrbulescu RF, Boehm CK, Soon E, Wilks MQ, Ilieş I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin MD, El Fakhri G, Orgill DP, Sluder AE, Poznansky MC

Am J Transplant. 2019 Feb 12. doi: 10.1111/ajt.15308. PMID:30748094
Alagpulinsa DA, Cao JJL, Driscoll K, Sirbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns T, Markmann JF, Melton DA and Poznansky MC.

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