To understand the mechanisms by which abnormal function of the bone marrow and hematopoietic stem cells may contribute to the etiology of disease, such as type 1 diabetes and associated cardiovascular disease, and to harness these insights for disease prevention and treatment.
The current focus of the Alagpulinsa lab is to use single cell analyses, genetic and pharmacologic manipulations, and targeted therapeutic delivery strategies to define alterations in the bone marrow and to treat type 1 diabetes in preclinical murine models.
- Single cell analysis of the bone marrow microenvironment in type 1 diabetes
- Development of strategies to restore bone marrow function in type 1 diabetes
- Development of strategies for targeted delivery of therapeutic cargo to the pancreatic islets
- Approaches to immunoprotect endogenous and transplanted beta cells for type 1 diabetes
PLos One, 2022; 30;17(12):e0279913. PMID: 36584183. Alagpulinsa DA, Toribio M, Awadalla M, Drobni ZD, Silva TQAC, Wang M, Durbin CG, Fourman LT, Abreu GAS, Nelson MD, Stanley TL, Longenecker CT, Burdo TH, Neilan TG, Zanni MV.
AIDS, 2023; 37(2): p. 305-310. PMID: 36541642. Alagpulinsa DA, Robinson JA, Toribio M, Quinaglia T, Awadalla M, Talathi R, Durbin CG, Alhallak I, Fourman LT, Suero-Abreu GA, Nelson MD, Stanley TL, Longenecker CT, Szczepaniak LS, Jerosch-Herold M, Neilan TG, Zanni M, Burdo TH.
Trends in Molecular Medicine, 2022. 28(5):360-377. PMID: 35341686. Alagpulinsa DA*, Toribio MP, Iad A and Shmookler Reis RJ.
Biomaterials, 2021. 268: p. 120482. PM1D: 33307367. Alolga RN#, Opoku-Damoah Y#, Alagpulinsa DA#, Huang FQ, Ma G, Yin X, Chavez MASC, Kudzai LC,Qi LW, Ding Y.
Trends in Cancer, 2020; S2405- 8033(20)30161-8. PMID: 32487486. Alagpulinsa DA, Szalat R, Poznansky MC, Shmookler Reis RJ.
Blood Advances, 2019; 3(23):3968-3972.PMID: 31805191. Alagpulinsa DA, Kumar S, Talluri S, Nanjappa P, Buon L, Chakraborty C, Samur M, Szalat R, Shammas MA, Munshi NC.
American Journal of Transplantation, 2019; 19(7):1930-1940. PMID: 30748094. Alagpulinsa DA, Cao JLL, Driscoll RK, Sȋbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns T, Markmann JF, Melton DA, Poznansky MC.
Pharmacology & Therapeutics. 2019; 193:63-74. PMID: 30149101. Alagpulinsa DA, Cao JLL, Sobell D, Poznansky MC.
Molecular Cancer Therapeutics, 2016; 15(2):241-250. PMID: 26719576. Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ.
Cancer Biology & Therapy, 2015; 6:976-986. PMID: 25996477. Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ.
Frontiers in Oncology, 2014; 4:289. PMID: 25401086. Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ.
2017 Mr. Riley Driscoll Brigham Young Student
2018 Ms. Rachel Shulmister Christopher Newport University Student
2018 Mr. Jeffrey Okewunmi Brown University Student
2020 Ms. Arpita Jajoo Tufts University Medical School Medical Student