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Ruxandra F. Sîrbulescu, PhD

Principal Investigator

Dr. Ruxandra Sîrbulescu is a Principal Investigator in the Vaccine and Immunotherapy Center, Instructor in Investigation at Massachusetts General Hospital, and Instructor of Medicine at Harvard Medical School. Dr. Sîrbulescu is a trained neurobiologist whose research interests focus on regenerative medicine.

The Sîrbulescu Laboratory is interested in developing novel cell-based (immuno)therapies for the treatment of chronic wounds and nervous system injuries, as well as in understanding the mechanisms that underlie the capacity of certain cells to initiate and accelerate tissue healing.

A key area of interest in the group is the non-canonical use of mature B lymphocytes as a novel cell-based immunomodulatory therapeutic strategy that can effectively enhance the progression of tissue repair.

The appropriate characterization of the molecular microenvironment of injured and regenerating tissues is essential for a mechanistic understanding of disease states. Current collaborative efforts in the context of diabetes and wound healing focus on developing a prognostic assay based on a combination of mass spectrometry imaging and imaging mass cytometry, that can be used to distinguish molecular signatures characteristic of wounds with good and poor healing prognosis and identify molecular profiles associated with response to treatment.

Dr. Sîrbulescu’s innovative research has been recognized through multiple publications, media articles, patents, and distinctions, including the Melvin Field Innovation Award, and several Excellence in Innovation certificates from Partners Healthcare.

Prior Experience

Dr. Sîrbulescu received a Fellowship from the Ernst A.C. Lange Foundation to conduct her PhD in Cell Biology and Neuroscience at Jacobs University in Germany, working on models of central nervous system injury and repair. During a postdoctoral program in Neurobiology at Northeastern University in Boston, Dr. Sîrbulescu continued her work on mechanisms of central nervous
system development, injury, and regeneration, and trained in multiple imaging modalities, including mass spectrometry imaging techniques.

Outside of VIC

Dr. Sîrbulescu is a member of the Institutional Animal Care and Use Committee (IACUC) of Massachusetts General Hospital.

Academic Credentials