Dr. Dusan Hanidziar is an anesthesiologist and intensivist at Massachusetts General Hospital and associate member of the Vaccine and Immunotherapy Center. His research group studies immune mechanisms of acute respiratory distress syndrome (ARDS) and the impact of hyperoxia on the lungs. He has received grant awards from the National Institutes of Health to study functions of pulmonary NKT cells and B cells during hyperoxic acute lung injury. Current collaborative projects investigate protective functions of B cells in the setting of acute lung injury and adoptive B cell therapy as an innovative approach to the treatment of ARDS.
Dhanidziar@mgb.org
After obtaining his doctoral degrees, Dr. Hanidziar completed basic science training in immunology as an NIH F32 fellow (Beth Israel Deaconess Medical Center) and subsequently trained in anesthesiology (Tufts Medical Center) and critical care medicine (Massachusetts General Hospital). He remained on staff at Massachusetts General Hospital as an attending anesthesiologist and intensivist.
His clinical expertise is in the management of mechanical ventilation and sedation in patients with ARDS. His research in acute lung injury was recognized by awards from several academic societies (International Anesthesia Research Society, Society of Critical Care Anesthesiologists). Dr. Hanidziar has mentored clinical fellows, residents and research trainees, all of whom published original work and review articles, in addition to presentations at national scientific meetings.
- MD Safarik University School of Medicine, Kosice, Slovakia
- PhD Johannes Gutenberg University, Mainz, Germany
- Diplomate Anesthesiology (American Board of Anesthesiology)
- Diplomate Critical Care Medicine (American Board of Anesthesiology)
Dr. Hanidziar is a member of research committees of American Society of Anesthesiologists, Society of Critical Care Medicine, International Anesthesia Research Society, and Society of Critical Care Anesthesiologists. He has served as a grant reviewer for the NIH and international funding agencies.
Hanidziar D, Dwyer LJ, Ranjeva SL, Csizmadia E, Maheshwari S, Valencia JD, Aspden JW, Farhat N, Otterbein LE, Robson SC, Sîrbulescu RF, Poznansky MC. Protective and Immunomodulatory Functions of Exogenous B Cells in Experimental Hyperoxic Lung Injury. Anesth Analg. 2025 Jun 23. doi: 10.1213/ANE.0000000000007545. Epub ahead of print. PMID: 40549576.
Kawai K, Stowe AM, Evans CL, Sîrbulescu RF, Hanidziar D, Lee KM, Tedder TF, Poznansky MC. The 2021 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, April 21, 2021. FASEB J. 2021 Aug;35(8):e21744. PMID: 34224602.
Hanidziar D, Robson SC. Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19. Am J Physiol Lung Cell Mol Physiol. 2021 Jan 1;320(1):L12-L16. PMID: 33050737
Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, Rosenthal A, Worrall D, Giguel F, Piechocka-Trocha A, Atyeo C, Fischinger S, Chan A, Flaherty KT, Hall K, Dougan M, Ryan ET, Gillespie E, Chishti R, Li Y, Jilg N, Hanidziar D, Baron RM, Baden L, Tsibris AM, Armstrong KA, Kuritzkes DR, Alter G, Walker BD, Yu X, Li JZ; Massachusetts Consortium for Pathogen Readiness. SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nat Commun. 2020 Oct 30;11(1):5493.PMID: 33127906
Hanidziar D, Nakahori Y, Cahill LA, Gallo D, Keegan JW, Nguyen JP, Otterbein LE, Lederer JA, Robson SC. Characterization of pulmonary immune responses to hyperoxia by high-dimensional mass cytometry analyses. Sci Rep. 2020 Mar 13;10(1):4677. PMID: 32170168.
Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC. Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury. Am J Resp Cell Mol Biol 2013, 48(5):601-9. PMID: 23349052
Dwyer KM, Hanidziar D, Putheti P, Hill PA, Pommey S, McRae JL, Winterhalter A, Doherty G, Deaglio S, Koulmanda M, Gao W, Robson SC, Strom TB. Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype. Am J Transplant. 2010 Nov;10(11):2410-20.
B cells for treatment of ARDS
NIH
R56HL175336
Role: Principal Investigator
Protective role of B cells in hyperoxic lung injury
NIH
R03HL171347
Role: Principal Investigator
Purinergic Modulation of NKT Cells Ameliorates Hyperoxic Lung Injury
NIH
K08HL141694
Role: Principal Investigator