POZNANSKY LAB
Mission Statement:
Research Focus:
VIC Projects List
- Distributed development of vaccines for cancer and emerging infectious diseases including COVID-19 and Coxiella burnetii.
- Development of novel combination immune therapies for cancer including CXCR4 antagonism
- Development and testing of an immune repellent microencapsulant containing CXCL12 to enable islet transplantation for Type 1 diabetes without systemic immune suppression
- Exploration of the use of High Dimensional Immunology (HDI) (including cell and tissue CyTOF, RNAseq and Mass Spec Imaging) to profile and image the immune system in human disease (including mesothelioma and prostate cancer) in order to explore novel pathogenic mechanisms and therapeutic approaches.
- Development of novel B cell based therapies for tissue injury and neurodegenerative diseases including ALS.
Highlighted Publications
Hum Vaccin Immunother. 2017 Dec 2;13(12):2977-2981. PMID: 28933682 Reeves PM, Paul SR. Sluder AE, Brauns, TA, Poznansky MC.
Front Immunol. 2019 Feb 15;10:207. doi: 10.3389/fimmu.2019.00207. eCollection 2019.PMID: 30828331 Scholzen A, Richard G, Moise L, Baeten LA, Reeves PM, Martin WD, Brauns TA, Boyle CM, Raju Paul S, Bucala R, Bowen RA, Garritsen A, De Groot AS, Sluder AE, Poznansky MC.
Hum Vaccin Immunother. 2012 Jul 1;8(7):1010-1012. PMID: 22777091 Leblanc P, Yuan J, Brauns T, Gelfand JA, Poznansky MC.
Accepted Jan 2019 FASEB PMID: 30802149 Zeng Y, Li B, Liang Y, Reeves PM, Liu Q, Qu X, Ran C, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC.
Cancer Research. 2011 Aug 15;71(16):5522- 5534. PMID: 21742774 Righi E, Kashiwagi S, Yuan J, Santosuosso M, Leblanc PR, Ingraham R, Forbes B, Edelblute B, Collette B, Xing D, Kowalski M, Mingari MC, Vianello F, Birrer M, Orsulic S, Dranoff G, and Poznansky MC.
Nat Med. 2000; 6: 543-548 PMID: 10802710 Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD and Scadden DT.
Cancer Immunol Res. 2018 May;6(5):539-551. PMID: 29511032 Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC.
Int J Cancer Clin Res. 2016 3:051 ISSN: 2378-3419 (*MCP and HC contributed equally). Zeng Y, Li B, Reeves PM, Ran C, Liu Z, Agha-Abbaslou M, Yuan J, Leblanc P, Sluder AE, Gelfand JA, Brauns T, Poznansky MC*, and Chen H*
Transplant Direct. 2019 Apr 15;5(5):e447. doi: 10.1097/TXD.0000000000000890. eCollection 2019 May. PMID:31165082 Sremac M, Lei, J, Penson MF.E., Schuetz C, Lakey JRT, Papas, KK, Varde PS, de Vos P, Hering B, Brauns T, Markmann J, Poznansky MC.
Am J Transplant. 2019 Feb 12. doi: 10.1111/ajt.15308. PMID:30748094 Alagpulinsa DA, Cao JJL, Driscoll K, Sirbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns T, Markmann JF, Melton DA and Poznansky MC.
Pharmacol Ther. 2018 Aug 24. pii: S0163- 7258(18)30149-9. doi: 10.1016/ j.pharmthera.2018.08.011 PMID: 30149101
Alagpulinsa DA, Cao JJL, Sobell D and Poznansky MC.
Research team
Susan Raju Paul, MD
Divya Mirgh, BTech, MS
Yohannes Gemechu Hailu, PhD
Sonia Mukherjee, MS
Nicholas Surguladze, BS
Richard Dzeng, MS
Fatma Dogan, PhD
Mohammad Omar Faruk Shaikh, PhD
Tyler Roady, BS
2021 David Gregory, PhD
2021 David Verrill, MS
2021 Emily Hill, BS Emory and Henry College
2020-2021 Kento Kawai, PhD. Medical degree program at Emory University, Georgia
2014-2015 Abhinbhen Saraya Wasontiwong, MD. Assistant Professor of Neurology, King Chulalongkorn Memorial Hospital, Thailand
2009-2018 Satoshi Kashiwagi, MD, PhD. Assistant Professor of Radiology MGH/Harvard Medical School Instructor.
2009-2014 Jianping Yuan, PhD. Research scientist at Novartis Institutes for BioMedical Research.
2007-2011 Michael Santosuosso, PhD. Medical Science Liaison Sunovion Pharmaceuticals, Canada.
2007-2011 Elda Righi, MD, PhD. Infectious Diseases Division, Santa Maria della Misericordia University Hospital, Italy.
2006-2009 Choli Hartono, MD. Assistant Professor of Medicine in Clinical Surgery & Assistant Professor in Clinical Medicine, Weill Cornell Medical College.
2005-2007 Liljana Stevceva, MD, PhD. Professor of Immunology & Pediatrics, California Northstate University College of Medicine. Consultant, Medical Education and Research Institute and previous Director of Division of Microbiology and Infectious Disease, Professor of Immunology and Microbiology, University of Texas
2005-2009 Fatimah Jaafar, PhD. Head of Human Resource, Ministry of Health, Brunei Darussalem.
2003-2004 Athe Tsibris, MD. Associate Physician, Brigham and Women’s Hospital and Assistant Professor of Medicine, Harvard Medical School
2002-2008 Fabrizio Vianello, MD. Associate Professor of Hematology and Immunology, Department of Medicine, University of Padua, Italy.
2002-2004 Diana Brainard, MD. Senior Vice President, Clinical Research Gilead Sciences.
2001-2006 William G Tharp, MD, PhD. Clinical Instructor, Department of Medicine, University of Vermont.
1998-2000 Richard Evans, MD. Clinical Board Director Cardiff and Vale University Health Board, UK
1995-1999 Gregor Adams, PhD. Assistant Professor, Cell & Neurobiology, Zilkha Neurogenetic Institute Keck School of Medicine and Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research. Director of Scientific Development MI Bioresearch, California