To enhance immunoprotection and support of transplanted allogeneic islets without systemic immune suppression to cure diabetes in a murine model. To develop efficacious and safe novel therapies for targeted delivery of therapeutic cargo to the graft to treat and prevent type 1 diabetes (T1D).
The Dogan Laboratory is pioneering research in the development of microgels containing CXCL12 and FasL with the ultimate goal of facilitating allo-islet transplantation for T1D without concurrent use of systemic immunosuppression. Additionally, our focus is to develop a novel, safe and effective islet-targeted gene delivery system to restore and enhance immune protection of the pancreatic islets in early-stage patients.
- Combining different approaches to achieve enhanced immunoprotection and support of transplanted allogeneic islets without the concurrent use of systemic immunosuppression to cure T1D.
- Using state-of-art technologies to deliver an immunomodulatory gene/ therapeutic cargo to the pancreatic islets, with the potential for translation to clinical trials and for economic large-scale application.
- Targeting the proinsulin processing pathway to prevent and/or reverse T1D.
- B cell immunotherapy for T1D: Improving beta cell survival and function in T1D through immunomodulatory tissue-protective B cell therapy.
- Imaging Mass Cytometry (IMC): Investigation of immune cell composition and cell-cell interactions within the islet graft microenvironment to discover novel targets for graft acceptance.
Faseb BioAdvances 2023; 5: 287-304. doi:10.1096/fba.2023-0002900:1–18. Lu, K.; Brauns, T.; Sluder, A. E.; Poznansky, M. C.; Dogan F.
Cancers (Basel). 2021 Mar 10;13(6):1213. doi:10.3390/cancers13061213. PMID: 33802026; PMCID: PMC8000866. Dogan, F.; Forsyth, N.R.
Cells. 2021 Apr 27;10(5):1032. doi: 10.3390/cells10051032. PMID: 33925659; PMCID: PMC8145390. Dogan, F.; Aljumaily, R.M.K.; Kitchen, M.; Forsyth, N.R.
Int J Low Extrem Wounds. 2020 Mar 4:1534734620907773. doi:10.1177/1534734620907773. Epub ahead of print. PMID: 32131656. Çetinkalp Ş, Gökçe EH, Şimşir I, Tuncay Tanrıverdi S, Doğan F, Biray Avcı Ç, Eroğlu İ, Utku T, Gündüz C, Özer Ö.
J Cell Biochem. 2019 Jan;120(1):380-395. doi:10.1002/jcb.27393. Epub 2018 Aug 26. PMID: 30145828. Sogutlu F, Kayabasi C, Ozmen Yelken B, Asik A, Gasimli R, Dogan F, Yilmaz Süslüer S, Biray Avcı C, Gunduz C.
J Cell Biochem. 2018 Dec;119(12):9817-9824. doi:10.1002/jcb.27301. Epub 2018 Aug 26. PMID: 30145821. Biray Avci C, Dogan F, Ozates Ay NP, Goker Bagca B, Abbaszadeh Z, Gunduz C.
J Cell Biochem. 2019 Feb;120(2):1282-1293. doi: 10.1002/jcb.27089. Epub 2018 Oct 28. PMID: 30368861. Dogan, F., Ozates Ay NP, Goker Bagca B, Z. Abbaszadeh, Söğütlü F.,Gasımlı R., Gündüz C, Ç. B. Avcı, 2018
Gene. 2018 Jan 30;641:235-239. doi: 10.1016/j.gene.2017.09.072. Epub 2017 Oct 24. PMID: 29074462. Dogan, F. & Avci, C. B., 2017.
Ben Shaer, student of Gann Academy, Waltham
Jihra James, BS candidate, Langston University
Aaruni Arora, MEng, Imperial College of London, United Kingdom
Katie Lu, BS, Stanford University, California
Esin Ozkan, MD candidate, Bezmialem Vakif University, Turkey