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Mukerji Lab

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Mission Statement:

Neurological complications from infections include cognitive changes and depression. We study systemic indicators of health, immune function and metabolite networks to advance our understanding and management of neurological disorders after infections.

Research Focus:

The Mukerji Lab employs computational approaches to characterize and develop treatment options for depression and other neuropsychological comorbidities in people with HIV on antiretroviral therapy.

VIC Projects List

  • Depression: Immune and metabolite biomarkers for depression in people with HIV. The role of neuroactive steroids and stress response in depressive symptoms. Peripheral immune correlates of neuroglial dysfunction in depression or pain.
MGH Lab website

Highlighted Publications

Low Neuroactive Steroids Identifies a Biological Subtype of Depression in Adults with Human Immunodeficiency Virus on Suppressive Antiretroviral Therapy.

J Infect Dis, 223(9), 1601-1611. Mukerji, S. S., Misra, V., Lorenz, D. R., Chettimada, S., Keller, K., Letendre, S., Ellis, R. J., Morgello, S., Parker, R. A., & Gabuzda, D. (2021, May 20).

Impact of Antiretroviral Regimens on Cerebrospinal Fluid Viral Escape in a Prospective Multicohort Study of Antiretroviral Therapy-Experienced Human Immunodeficiency Virus-1-Infected Adults in the United States.

Clin Infect Dis, 67(8), 1182- 1190. Mukerji, S. S., Misra, V., Lorenz, D. R., Uno, H., Morgello, S., Franklin, D., Ellis, R. J., Letendre, S., & Gabuzda, D. (2018, Sep 28).

Longitudinal Modeling of Depressive Trajectories Among HIV-Infected Men Using Cocaine.

AIDS Behav, 21(7), 1985-1995. Mukerji, S., Haghighat, R., Misra, V., Lorenz, D. R., Holman, A., Dutta, A., & Gabuzda, D. (2017, Jul).

Lipid Profiles and APOE4 Allele Impact Midlife Cognitive Decline in HIV-Infected Men on Antiretroviral Therapy.

Clin Infect Dis, 63(8), 1130-1139. Mukerji, S. S., Locascio, J. J., Misra, V., Lorenz, D. R., Holman, A., Dutta, A., Penugonda, S., Wolinsky, S. M., & Gabuzda, D. (2016, Oct 15).

HIV increases sleep-based brain age despite antiretroviral therapy.

Sleep, 44(8). Leone, M. J., Sun, H., Boutros, C. L., Liu, L., Ye, E., Sullivan, L., Thomas, R. J., Robbins, G. K., Mukerji, S. S., & Westover, M. B. (2021, Aug 13).

Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patients.

J Neurol Sci, 430, 120023. Normandin, E., Holroyd, K. B., Collens, S. I., Shaw, B. M., Siddle, K. J., Adams, G., Rudy, M., Solomon, I. H., Anahtar, M. N., Lemieux, J. E., Trombetta, B. A., Kivisakk, P., Arnold, S. E., Rapalino, O., Piantadosi, A. L., Sen, P., Rosenberg, E. S., Branda, J., Sabeti, P. C., & Mukerji, S. S. (2021, Oct 4).
View Full List of Lab Publications VIA PUBMED

Research Team

Emily Rudmann

Clinical Research Coordinator I

Elissa Ye

Data Scientist

Navid Valizadeh

Clinical Research Fellow

Haitham Alabsi

Neurology Faculty, Staff

Doug Wilcox

Neurology Resident

 

 

2019 – 2021 Sarah Collens, BS. Precision Medicine Associate II at Regeneron
2018 – 2020 Kiana Keller, BS. MD candidate at Uniformed Services University School of Medicine
2017-2018 Mike Leone, BS. MD-PhD candidate at University of Pittsburgh

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