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Sîrbulescu Lab

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Mission Statement:

To develop innovative therapeutic solutions for tissue repair and regeneration.

Research Focus:

The Sîrbulescu Laboratory is interested in developing novel cell- based immunotherapies for the treatment of difficult and chronic wounds, traumatic nervous system injuries, and neurodegenerative diseases and in understanding the mechanisms that allow certain cells to exert their pro-healing functions. Our work falls within the larger scope of regenerative medicine.

VIC Projects List

  • Wound Healing: B cell immunotherapy for acute and chronic wound healing, Mechanisms of B cell action in the context of wound healing, Novel anti-bacterial therapeutics for chronic diabetic ulcers, CXCL12 as an immunomodulatory therapeutic in wound healing
  • Traumatic Brain Injury: B cell immunotherapy for contusion traumatic brain injury, Immunomodulatory interactions of B cells in neurotrauma
  • Amyotrophic Lateral Sclerosis (ALS): Immunomodulatory systemic B cell therapy for ALS, Immune profiling in patients with slow- and rapid-progression of ALS
  • Multi-modal mass spectrometry-based imaging: Mass spectrometry imaging and imaging mass cytometry for improving diagnosis, prognosis and biomarker discovery based on clinical tissue biopsies

Highlighted Publications

Intraparenchymal Application of Mature B Lymphocytes Improves Structural and Functional Outcome after Contusion Traumatic Brain Injury.

J Neurotrauma. 2019 Apr 18. doi: 10.1089/neu.2018.6368. PMID: 30997843 Sîrbulescu RF, Chung JY, Edmiston WJ, Poznansky SA, Poznansky MC, Whalen M.

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions.

Wound Repair Regen. 2017 Sep;25(5):774-791 PMID: 28922523 Sîrbulescu RF, Boehm CK, Soon E, Wilks MQ, Ilieş I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin MD, El Fakhri G, Orgill DP, Sluder AE, Poznansky MC.

Additive neurogenesis supported by multiple stem cell populations mediates adult spinal cord development: A spatiotemporal statistical mapping analysis in a teleost model of indeterminate growth. Dev Neurobiol.

2017 Nov;77(11):1269-1307. doi: 10.1002/dneu.22511. Epub 2017 Jul 23. PMID: 28707354
Sîrbulescu RF, Ilieş I, Meyer A, Zupanc GKH.

Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.

Am J Transplant. 2019 Feb 12. doi: 10.1111/ajt.15308. PMID:30748094 Alagpulinsa DA, Cao JJL, Driscoll K, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns T, Markmann JF, Melton DA and Poznansky MC.

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits. BMC Neurosci.

2011 Jul 27;12:74. doi: 10.1186/1471-2202-12-74. PMID: 21794126 Dauth S, Sîrbulescu RF, Jordans S, Rehders M, Avena L, Oswald J, Lerchl A, Saftig P, Brix K.

Structural and functional regeneration after spinal cord injury in the weakly electric teleost fish, Apteronotus leptorhynchus.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009 Jul;195(7):699-714. doi: 10.1007/s00359-009-0445-4. Epub 2009 May 10. PMID: 19430939 Sîrbulescu RF, Ilieş I, Zupanc GK.

View Full List of Lab Publications VIA PUBMED

Research Team

Ruxandra Sîrbulescu, PhD

Principal Investigator

Gina Jin, B. Sc.

Research Technician I

Michael H. Chapin, B. Sc.

Lab Manager

Joshua M. Hess, B. Sc.

HDI Data Analysis Technician

Laura Valine, B. Sc.

HDI Cell Assay Technician

 

 

2015-2018 Chloe K. Boehm, BS. Research Associate at The Broad Institute of Harvard and MIT
2016 Erin P.Y. Soon, BS. Graduate Student at Stanford University
2016-2017 Benjamin Maxner, BS. MD Candidate, University of Massachusetts Medical School
2017 Akshay Mamidi, BS. Process Engineer at Abbott Laboratories, Singapore
2017-2018 Gabriela Funez-dePagnier, BS. Research Assistant at Weill Cornell Medical College
2017 Anders Erickson, BSc. MD Candidate, Toronto University Medical School, Canada
2017 Claire S.Y. Chan, B.Sc. Undergraduate Student, Imperial College London, UK 2017 William Porter Undergraduate Student
2018 Dominique Kiki Carey, BS. Teaching Assistant at University of Massachusetts Amherst
2018 Petra Paisz, BS. MD/PhD Candidate, Imperial College London, UK
2019 Orla Mostyn Williams, MSc. MD Candidate, Imperial College London, UK

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