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REEVES LAB

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Mission Statement:

Detailed interrogation of the immune system to drive development of vaccines and therapeutic strategies for cancer and infectious diseases.

Research Focus:

Work in the Reeves Laboratory investigates mechanisms governing the immune response to disease, with particular interest in intracellular pathogens and solid tumors. Across projects, we apply deep-immune profiling and computational approaches to gain a more detailed understanding of the interface of the immune system with disease and the levers of effective immune-modulating therapies.

VIC Projects List

  • Infectious Disease Vaccine Development, Modular vaccine platform for rapid response to emerging infections, Detailed immunophenotyping of murine and clinical samples following infection or vaccination, Current vaccine projects: Q fever, influenza
  • Immune Modulation to Combat Cancer, Tumor immune evasion, Modular vaccine platform for tailored individual cancer vaccines, Combination therapies to improve anti-tumor responses, Repurposing FDA approved drugs to shorten time to clinic, Detailed and broad profiling of the immune system and tumors to inform treatment development
  • High-Dimensional Imaging to Map Features of Disease and Therapy, Building detailed molecular maps of tumors and diseased tissues to identify signatures of disease state and treatment response by integrating multi-modal data from: Imaging mass cytometry: organization and functional status of cell populations within tissues

Highlighted Publications

Coxiella burnetii Epitope-Specific T-Cell Responses in Patients with Chronic Q Fever.

2019 Sep 19;87(10). pii: e00213-19. doi: 10.1128/IAI.00213-19. Print 2019 Oct. PubMed PMID: 31331958 Scholzen A, Richard G, Moise L, Hartman E, Bleeker-Rovers CP, Reeves PM, Raju Paul S, Martin WD, De Groot AS, Poznansky MC, Sluder AE, Garritsen A.

Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine.

Front Immunol. 2019 Feb 15;10:207. doi: 10.3389/fimmu.2019.00207. eCollection 2019. PubMed PMID: 30828331 Scholzen A, Richard G, Moise L, Baeten LA, Reeves PM, Martin WD, Brauns TA, Boyle CM, Raju Paul S, Bucala R, Bowen RA, Garritsen A, De Groot AS, Sluder AE, Poznansky MC.

Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment.

FASEB J. 2019 May;33(5):6596-6608. doi: 10.1096/fj.201802067RR. Epub 2019 Feb 25. PubMed PMID: 30802149 Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC.

Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice.

Oncotarget. 2017 Oct 4;8(55):94040-94053. doi: 10.18632/oncotarget.21541. eCollection PMID: 29212208
Reeves PM, Abbaslou MA, Kools FRW, Vutipongsatorn K, Tong X, Gavegnano C, Schinazi RF, Poznansky MC.

Application and utility of mass cytometry in vaccine development.

FASEB J. 2018 Jan;32(1):5-15. doi: 0.1096/fj.201700325R. Epub 2017 Nov 1. Review. PubMed PMID: 29092906.
Reeves PM, Sluder AE, Paul SR, Scholzen A, Kashiwagi S, Poznansky MC.

Q-vaxcelerate: A distributed development approach for a new Coxiella burnetii vaccine.

2017 Dec 2;13(12):2977-2981. doi: 10.1080/21645515.2017.1371377. Epub 2017 Sep 21. Review. PubMed PMID: 28933682 Reeves PM, Paul SR, Sluder AE, Brauns TA, Poznansky MC.

CXCR4 blockade with AMD3100 enhances Taxol chemotherapy to limit ovarian cancer cell growth.

Anticancer Drugs. 2017 Oct;28(9):935-942. doi: 10.1097/CAD.0000000000000518. PubMed PMID: 28817386. Reeves PM, Abbaslou MA, Kools FRW, Poznansky MC.

Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway.

Traffic 2016 Jan;17(1):40-52. doi: 10.1111/tra.12343. Epub 2015 Dec 9. PubMed PMID: 26481905 Reeves PM, Kang YL, Kirchhausen T.

View Full List of Lab Publications VIA PUBMED

Research team

Patrick Reeves, PhD

Principal Investigator

John Iskra, Ph.D.

Visiting Professor, Emory & Henry College

Joshua M. Hess, B.Sc.

HDI Data Analysis Technician

Morgan Friesen, B.Sc.

Masters Student, Univ. of Utrecht

Laura Valine, B.Sc.

HDI Cell Assay Technician

 

 

2015-2019 Susan Raju Paul, MBBS

2017-2019 Yuexiong Yi, MD PhD – Surgeon Zhongnan Hospital

2018-2019 Shengdong Wang, MD – PhD student Zheijang University

2017-2019 Skylar Korek, B.Sc. MD/PhD student, Florida International University

2016-2017 Farah Kools, M.S. PhD Candidate, Utrecht University (Netherlands)

2016 Anita Vorha, B.Sc. Research Associate–Harvard Medical School

2016 Ellie Dunstone, B.Sc. PhD Candidate, Cambridge University (UK)

2016 Carl Pierce, B.Sc. MD/PhD Student, Albert Einstein Medical School

2015-2016 Ottavia Clemente, PhD Pharmaceutical Research Scientist

2015-2016 Xavier Catena, M.S. PhD Student, Spanish National Cancer Center

2015 Kritchai “Jay” Vutipongsatorn, B.Sc. MD Student, Imperial College, London

2015 Jan Orlewsky, M.D. Medical Resident

2014-2016 Mojgan Abbaslou, MD Medical Resident

2014 Samantha Wong, B.Sc. PhD Candidate, Harvard Medical School

ALUMNI