The Chen Laboratory focuses on developing novel molecule-based and cell-based immunotherapies for treatment of various cancers and understanding mechanism(s) by which HIV infection promotes the development or progression of tumors.
- Novel immunotherapies for mesothelin-expressing cancers that combine a mesothelin-targeted immune-activating fusion protein with blockade of PD-1/PD-L1 or CXCR4/CXCL12 pathway
- New subsets of mesenchymal stem cells (MSCs) and its derived extracellular vesicles/exosomes for treatment of various cancers
- Regulatory B cells (Breg) in the development of AIDS-related tumors
Oncotarget. 2019 Jul 8;10(43):4479-4491. Zeng Y, Li B, Li T, Liu W, Ran C, Penson RT, Poznansky MC, Du Y, Chen H.
Oncotarget. 2019 Jul 8;10(43):4479-4491. Zeng Y, Li B, Li T, Liu W, Ran C, Penson RT, Poznansky MC, Du Y, Chen H.
FASEB J. 2019 May;33(5):6596-6608 Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC.
Cancer Immunol Res. 2018 May;6(5):539-551 Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC.
Cancer Res. 2018 Jul 15;78(14):3938-3953 Li B, Wang Z, Wu H, Xue M, Lin P, Wang S, Lin N, Huang X, Pan W, Liu M, Yan X, Qu H, Sun L, Li H, Wu Y, Teng W, Wang Z, Zhou X, Chen H, Poznansky MC, Ye Z.
Nat Immunol. 2012 Jun 10;13(7):691-700 Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BD.
J Clin Invest. 2011 Apr;121(4):1549-60 Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M.
2015-2017 Binghao Li, MBBS. Physician at the Second Affiliated Hospital of Zhejiang University, China
2015 Peter Rees. Graduate student at Cambridge University, UK
2015-2017 Yang Zeng PhD. Research Fellow at DFCI, Boston
2017-2018 Xiying Qu, PhD. Instructor at MGH, Boston
2016 Alice Tang. Graduate student at Imperial College, UK
2016-2017 Qiuyan Liu, MD, PhD. Professor at the Second Military Medical University, China
2016-2017 Yingying Liang, MA. PhD candidate at University of Rochester, NY
2017 Reyna Niner. MD candidate at Tufts University, Boston
2018-2019 Xiang Li. Graduate student at Hongkong University, China