User Profile
  • 2012, BSc in Biomedical Sciences (Hons), University of Westminster, U.K
  • 2013, MSc in Medical Microbiology, London School of Hygiene and Tropical Medicine, U.K
  • 2017, PhD in Molecular Microbiology, Imperial College London, U.K
  • Leanse LG, Harrington OD, Fang Y, Ahmed I, Goh XS and Dai T (2018) Evaluating the Potential for Resistance Development to Antimicrobial Blue Light (at 405 nm) in Gram-Negative Bacteria: In vitro and in vivo Studies. Front. Microbiol. 9:2403. doi: 10.3389/fmicb.2018.02403
  • Li Y, Li Y, Fernandez Crespo R, Leanse LG, Langford PR, Bossé JT (2018). Characterization of the Actinobacillus pleuropneumoniae SXT-related integrative and conjugative element ICEApl2 and analysis of the encoded FloR protein: hydrophobic residues in transmembrane domains contribute dynamically to florfenicol and chloramphenicol efflux. J Antimicrob Chemother. Jan 01; 73(1):57-65. PMID: 29029160.
  • Bossé JT, Chaudhuri RR, Li Y, Leanse LG, Fernandez Crespo R, Coupland P, Holden MT, Bazzolli DM, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR (2016). Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae. Genome Announc. Jan 28; 4(1). PMID: 26823596; PMCID: PMC4732349.
  • Bossé JT, Li Y, Leanse LG, Zho, L,Peters SE, Wang J, Maglennon G, Holden MTG, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR, on behalf of the BRaDP1T consortium. (2018). Rationally designed mariner vectors to allow functional genomic analysis of Actinobacillus pleuropneumoniae and Pasteurella multocida by transposon-directed insertion-site sequencing (TraDIS). [Under review: Applied and Environmental Microbiology].
  • Leanse LG, Goh XS, Lu M, Hooper DC, Dai T (2018). Enhanced inactivation of Gram-negative multidrug-resistant bacterial isolates by antimicrobial blue light (405 nm) and quinine: in vitro and in vivo studies. [in preparation].
  • Leanse, LG, Bossé, JT, Li, Y, Li, Y, Langford, PR (2018). The development of an anhydrotetracycline inducible gene expression system for use in the Pasterellaceae. [in preparation].
  • 1. Combination therapies using antimicrobial blue light (aBL;405 nm) for potentiated inactivation of multi-drug resistant bacterial and fungal species
  • 2. Elucidating the mechanism of action of aBL using a combination of transposon mutagenesis and RNA-seq
  • 3. Evaluating the effect of aBL on microbial pathogenesis using Galleria mellonella as a model system
  • ASLMS research grant. Leanse (PI)
  • 07/01/18-06/30/18
  • American Society for Laser Medicine and Surgery
  • Investigation of the translatability of aBL-quinine combination therapy against an array of Gram-negative and Gram positive bacterial pathogens and an evaluation of the safeness of the
  • combination therapy approach using keratinocytes as the model mammalian cell line. In addition, the effect of aBL-quinine combination therapy on the bacterial transcriptome, using RNA-sequencing, will be investigated.