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  • B.S. Mechanical Engineering Soochow University, Suzhou, China
  • M.S. Mechanical Engineering China Agricultural University, Beijing, China
  • Ph.D. Mechanical Engineering China Agricultural University, Beijing, China
  • 1. Leanse LG, Harrington OD, Fang Y, Ahmed I, Goh XS, Dai T. Evaluating the potential for resistance development to antimicrobial blue light (at 405 nm) in Gram-negative bacteria: in vitro and in vivo studies. Front Microbiol. 2018 Oct 16; doi: 10.3389/fmicb.2018.02403
  • 2. Ahmed I, Fang Y, Lu M, Yan Q, El-Hussein AMK, Hamblin MR, Dai T. Recent Patents on Light-Based Anti-Infective Approaches. Recent Pat Antiinfect Drug Discov. 2018; 13:70-88. PMID: 29119936.
  • 3. Narita K, Asano K, Morimoto Y, Igarashi T, Hamblin MR, Dai T, Nakane A. Disinfection and healing effects of 222-nm UVC light on methicillin-resistant Staphylococcus aureus infection in mouse wounds. J Photochem Photobiol B. 2018; 178:10-18. PMID: 29101868.
  • 4. Wang Y, Wang Y, Wang Y, Murray CK, Hamblin MR, Hooper DC, Dai T. Antimicrobial blue light inactivation of pathogenic microbes: State of the art. Drug Resist Updat. 2017; 33-35:1-22. PMID: 29145971.
  • 5. Dai T, Hamblin MR. Visible Blue Light is Capable of Inactivating Candida albicans and Other Fungal Species. Photomed Laser Surg. 2017; 35(7):345-346. PMID: 28613980.
  • 6. Wang Y, Harrington OD, Wang Y, Murray CK, Hamblin MR, Dai T. In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging. J Vis Exp. 2017; (122). PMID: 28518072.
  • 7. Dai T. The antimicrobial effect of blue light: What are behind? Virulence. 2017; 8(6):649-652. PMID: 28051916.
  • 8. Zhu H, Kochevar IE, Behlau I, Zhao J, Wang F, Wang Y, Sun X, Hamblin MR, Dai T. Antimicrobial Blue Light Therapy for Infectious Keratitis: Ex Vivo and In Vivo Studies. Invest Ophthalmol Vis Sci. 2017; 58(1):586-593. PMID: 28129422.
  • 9. Kim M, An J, Kim KS, Choi M, Humar M, Kwok SJ, Dai T, Yun SH. Optical lens-microneedle array for percutaneous light delivery. Biomed Opt Express. 2016; 7(10):4220-4227. PMID: 27867727.
  • 10. Zhang Y, Zhu Y, Chen J, Wang Y, Sherwood ME, Murray CK, Vrahas MS, Hooper DC, Hamblin MR, Dai T. Antimicrobial blue light inactivation of Candida albicans: In vitro and in vivo studies. Virulence. 2016; 7(5):536-45. PMID: 26909654.
  • 11. Amin RM, Bhayana B, Hamblin MR, Dai T. Antimicrobial blue light inactivation of Pseudomonas aeruginosa by photo-excitation of endogenous porphyrins: In vitro and in vivo studies. Lasers Surg Med. 2016; 48(5):562-8. PMID: 26891084.
  • 12. Wang Y, Wu X, Chen J, Amin R, Lu M, Bhayana B, Zhao J, Murray CK, Hamblin MR, Hooper DC, Dai T. Antimicrobial Blue Light Inactivation of Gram-Negative Pathogens in Biofilms: In Vitro and In Vivo Studies. J Infect Dis. 2016; 213(9):1380-7. PMID: 26908743; PMCID: PMC4813746.
  • 13. Zhang Y, Dai T, Wang M, Vecchio D, Chiang LY, Hamblin MR. Potentiation of antimicrobial photodynamic inactivation mediated by a cationic fullerene by added iodide: in vitro and in vivo studies. Nanomedicine (Lond). 2015; 10(4):603-14. PMID: 25723093; PMCID: PMC4899971.
  • 14. Zhang Y, Zhu Y, Gupta A, Huang Y, Murray CK, Vrahas MS, Sherwood ME, Baer DG, Hamblin MR, Dai T. Antimicrobial blue light therapy for multidrug-resistant Acinetobacter baumannii infection in a mouse burn model: implications for prophylaxis and treatment of combat-related wound infections. J Infect Dis. 2014; 209(12):1963-71. PMID: 24381206; PMCID: PMC4038138.
  • 15. Gupta A, Avci P, Dai T, Huang YY, Hamblin MR. Ultraviolet Radiation in Wound Care: Sterilization and Stimulation. Adv Wound Care (New Rochelle). 2013; 2(8):422-437. PMID: 24527357.
  • 16. Yin R, Dai T, Avci P, Jorge AE, de Melo WC, Vecchio D, Huang YY, Gupta A, Hamblin MR. Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond. Curr Opin Pharmacol. 2013; 13(5):731-62. PMID: 24060701; PMCID: PMC3831650.
  • 17. de Melo WC, Avci P, de Oliveira MN, Gupta A, Vecchio D, Sadasivam M, Chandran R, Huang YY, Yin R, Perussi LR, Tegos GP, Perussi JR, Dai T, Hamblin MR. Photodynamic inactivation of biofilm: taking a lightly colored approach to stubborn infection. Expert Rev Anti Infect Ther. 2013; 11(7):669-93. PMID: 23879608; PMCID: PMC4336791.
  • 18. Huang L, Wang M, Dai T, Sperandio FF, Huang YY, Xuan Y, Chiang LY, Hamblin MR. Antimicrobial photodynamic therapy with decacationic monoadducts and bisadducts of [70]fullerene: in vitro and in vivo studies. Nanomedicine (Lond). 2014; 9(2):253-66. PMID: 23738632; PMCID: PMC3859801.
  • 19. Gupta A, Dai T, Hamblin MR. Effect of red and near-infrared wavelengths on low-level laser (light) therapy-induced healing of partial-thickness dermal abrasion in mice. Lasers Med Sci. 2014; 29(1):257-65. PMID: 23619627; PMCID: PMC3766381.
  • 20. Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hamblin MR. Linezolid and vancomycin decrease the therapeutic effect of methylene blue-photodynamic therapy in a mouse model of MRSA bacterial arthritis. Photochem Photobiol. 2013; 89(3):679-82. PMID: 23311407; PMCID: PMC3636181.
  • 21. Dai T, Gupta A, Huang YY, Sherwood ME, Murray CK, Vrahas MS, Kielian T, Hamblin MR. Blue light eliminates community-acquired methicillin-resistant Staphylococcus aureus in infected mouse skin abrasions. Photomed Laser Surg. 2013; 31(11):531-8. PMID: 23406384; PMCID: PMC3818001.
  • 22. Xuan W, Vatansever F, Huang L, Wu Q, Xuan Y, Dai T, Ando T, Xu T, Huang YY, Hamblin MR. Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: effect of treatment repetition regimen. PLoS One. 2013; 8(1):e53454. PMID: 23308226; PMCID: PMC3538543.
  • 23. Dai T, Gupta A, Huang YY, Yin R, Murray CK, Vrahas MS, Sherwood ME, Tegos GP, Hamblin MR. Blue light rescues mice from potentially fatal Pseudomonas aeruginosa burn infection: efficacy, safety, and mechanism of action. Antimicrob Agents Chemother. 2013 Mar; 57(3):1238-45. PMID: 23262998; PMCID: PMC3591931.
  • 24. Sperandio FF, Sharma SK, Wang M, Jeon S, Huang YY, Dai T, Nayka S, de Sousa SC, Chiang LY, Hamblin MR. Photoinduced electron-transfer mechanisms for radical-enhanced photodynamic therapy mediated by water-soluble decacationic C70 and C84O2 Fullerene Derivatives. Nanomedicine. 2013; 9(4):570-9. PMID: 23117043; PMCID: PMC3582824.
  • 25. St Denis TG, Dai T, Hamblin MR. Killing bacterial spores with blue light: when innate resistance meets the power of light. Photochem Photobiol. 2013; 89(1):2-4. PMID: 22946878; PMCID: PMC3556167.
  • 26. Vecchio D, Dai T, Huang L, Fantetti L, Roncucci G, Hamblin MR. Antimicrobial photodynamic therapy with RLP068 kills methicillin-resistant Staphylococcus aureus and improves wound healing in a mouse model of infected skin abrasion PDT with RLP068/Cl in infected mouse skin abrasion. J Biophotonics. 2013; 6(9):733-42. PMID: 22987338; PMCID: PMC3594622.
  • 27. Dai T, Murray CK, Vrahas MS, Baer DG, Tegos GP, Hamblin MR. Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination? J Trauma Acute Care Surg. 2012; 73(3):661-7. PMID: 22929495; PMCID: PMC3463377.
  • 28. Sharma SK, Mroz P, Dai T, Huang YY, St Denis TG, Hamblin MR. Photodynamic Therapy for Cancer and for Infections: What Is the Difference? Isr J Chem. 2012; 52(8-9):691-705. PMID: 23248387.
  • 29. Baxter RM, Dai T, Kimball J, Wang E, Hamblin MR, Wiesmann WP, McCarthy SJ, Baker SM. Chitosan dressing promotes healing in third degree burns in mice: gene expression analysis shows biphasic effects for rapid tissue regeneration and decreased fibrotic signaling. J Biomed Mater Res A. 2013; 101(2):340-8. PMID: 22847951; PMCID: PMC3488117.
  • 30. Dai T, Gupta A, Murray CK, Vrahas MS, Tegos GP, Hamblin MR. Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond? Drug Resist Updat. 2012; 15(4):223-36. PMID: 22846406; PMCID: PMC3438385.
  • 31. Tanaka M, Mroz P, Dai T, Huang L, Morimoto Y, Kinoshita M, Yoshihara Y, Nemoto K, Shinomiya N, Seki S, Hamblin MR. Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation. PLoS One. 2012; 7(6):e39823. PMID: 22761911; PMCID: PMC3383702.
  • 32. Dai T, Garcia B, Murray CK, Vrahas MS, Hamblin MR. UVC light prophylaxis for cutaneous wound infections in mice. Antimicrob Agents Chemother. 2012; 56(7):3841-8. PMID: 22564833; PMCID: PMC3393382.
  • 33. Dai T, Fuchs BB, Coleman JJ, Prates RA, Astrakas C, St Denis TG, Ribeiro MS, Mylonakis E, Hamblin MR, Tegos GP. Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform. Front Microbiol. 2012; 3:120. PMID: 22514547; PMCID: PMC3322354.
  • 34. Huang YY, Sharma SK, Dai T, Chung H, Yaroslavsky A, Garcia-Diaz M, Chang J, Chiang LY, Hamblin MR. Can nanotechnology potentiate photodynamic therapy? Nanotechnol Rev. 2012; 1(2):111-146. PMID: 26361572.
  • 35. Vera DM, Haynes MH, Ball AR, Dai T, Astrakas C, Kelso MJ, Hamblin MR, Tegos GP. Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes. Photochem Photobiol. 2012; 88(3):499-511. PMID: 22242675; PMCID: PMC3345078.
  • 36. Dai T, Vrahas MS, Murray CK, Hamblin MR. Ultraviolet C irradiation: an alternative antimicrobial approach to localized infections? Expert Rev Anti Infect Ther. 2012; 10(2):185-95. PMID: 22339192; PMCID: PMC3292282.
  • 37. Chung H, Dai T, Sharma SK, Huang YY, Carroll JD, Hamblin MR. The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng. 2012; 40(2):516-33. PMID: 22045511; PMCID: PMC3288797.
  • 38. St Denis TG, Dai T, Izikson L, Astrakas C, Anderson RR, Hamblin MR, Tegos GP. All you need is light: antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease. Virulence. 2011; 2(6):509-20. PMID: 21971183; PMCID: PMC3260545.
  • 39. Tanaka M, Kinoshita M, Yoshihara Y, Shinomiya N, Seki S, Nemoto K, Hirayama T, Dai T, Huang L, Hamblin MR, Morimoto Y. Optimal photosensitizers for photodynamic therapy of infections should kill bacteria but spare neutrophils. Photochem Photobiol. 2012; 88(1):227-32. PMID: 21950417; PMCID: PMC3253242.
  • 40. Ando T, Xuan W, Xu T, Dai T, Sharma SK, Kharkwal GB, Huang YY, Wu Q, Whalen MJ, Sato S, Obara M, Hamblin MR. Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice. PLoS One. 2011; 6(10):e26212. PMID: 22028832; PMCID: PMC3196530.
  • 41. Dai T, Bil de Arce VJ, Tegos GP, Hamblin MR. Blue dye and red light, a dynamic combination for prophylaxis and treatment of cutaneous Candida albicans infections in mice. Antimicrob Agents Chemother. 2011; 55(12):5710-7. PMID: 21930868; PMCID: PMC3232820.
  • 42. Kharkwal GB, Sharma SK, Huang YY, Dai T, Hamblin MR. Photodynamic therapy for infections: clinical applications. Lasers Surg Med. 2011; 43(7):755-67. PMID: 22057503; PMCID: PMC3449167.
  • 43. Dai T, Tanaka M, Huang YY, Hamblin MR. Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects. Expert Rev Anti Infect Ther. 2011; 9(7):857-79. PMID: 21810057; PMCID: PMC3188448.
  • 44. Dai T, Kharkwal GB, Tanaka M, Huang YY, Bil de Arce VJ, Hamblin MR. Animal models of external traumatic wound infections. Virulence. 2011; 2(4):296-315. PMID: 21701256; PMCID: PMC3173676.
  • 45. Mroz P, Xia Y, Asanuma D, Konopko A, Zhiyentayev T, Huang YY, Sharma SK, Dai T, Khan UJ, Wharton T, Hamblin MR. Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma. Nanomedicine. 2011; 7(6):965-74. PMID: 21645643; PMCID: PMC3183379.
  • 46. Huang L, Dai T, Xuan Y, Tegos GP, Hamblin MR. Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections. Antimicrob Agents Chemother. 2011; 55(7):3432-8. PMID: 21502618; PMCID: PMC3122390.
  • 47. Wainwright M, Dai T, Hamblin MR. Antimicrobial photodynamic therapy in the colon: delivering a light punch to the guts? Photochem Photobiol. 2011; 87(4):754-6. PMID: 21418077; PMCID: PMC3132272.
  • 48. St Denis TG, Huang L, Dai T, Hamblin MR. Analysis of the bacterial heat shock response to photodynamic therapy-mediated oxidative stress. Photochem Photobiol. 2011; 87(3):707-13. PMID: 21261628; PMCID: PMC3082629.
  • 49. Dai T, Kharkwal GB, Zhao J, St Denis TG, Wu Q, Xia Y, Huang L, Sharma SK, d'Enfert C, Hamblin MR. Ultraviolet-C light for treatment of Candida albicans burn infection in mice. Photochem Photobiol. 2011; 87(2):342-9. PMID: 21208209; PMCID: PMC3048910.
  • 50. Sharma SK, Dai T, Kharkwal GB, Huang YY, Huang L, De Arce VJ, Tegos GP, Hamblin MR. Drug discovery of antimicrobial photosensitizers using animal models. Curr Pharm Des. 2011; 17(13):1303-19. PMID: 21504410.
  • 51. Lu Z, Dai T, Huang L, Kurup DB, Tegos GP, Jahnke A, Wharton T, Hamblin MR. Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections. Nanomedicine (Lond). 2010; 5(10):1525-33. PMID: 21143031; PMCID: PMC3047412.
  • 52. Dai T, Tegos GP, St Denis TG, Anderson D, Sinofsky E, Hamblin MR. Ultraviolet-C irradiation for prevention of central venous catheter-related infections: an in vitro study. Photochem Photobiol. 2011; 87(1):250-5. PMID: 21073470; PMCID: PMC3010268.
  • 53. Ragàs X, Sánchez-García D, Ruiz-González R, Dai T, Agut M, Hamblin MR, Nonell S. Cationic porphycenes as potential photosensitizers for antimicrobial photodynamic therapy. J Med Chem. 2010; 53(21):7796-803. PMID: 20936792; PMCID: PMC2981434.
  • 54. Katz TM, Glaich AS, Goldberg LH, Firoz BF, Dai T, Friedman PM. Treatment of melasma using fractional photothermolysis: a report of eight cases with long-term follow-up. Dermatol Surg. 2010; 36(8):1273-80. PMID: 20666816.
  • 55. Ragàs X, Dai T, Tegos GP, Agut M, Nonell S, Hamblin MR. Photodynamic inactivation of Acinetobacter baumannii using phenothiazinium dyes: in vitro and in vivo studies. Lasers Surg Med. 2010; 42(5):384-90. PMID: 20583252; PMCID: PMC2935797.
  • 56. Hamblin MR, Dai T. Can surgical site infections be treated by photodynamic therapy? Photodiagnosis Photodyn Ther. 2010; 7(2):134-6. PMID: 20510311; PMCID: PMC2945525.
  • 57. Dai T, Huang YY, Sharma SK, Hashmi JT, Kurup DB, Hamblin MR. Topical antimicrobials for burn wound infections. Recent Pat Antiinfect Drug Discov. 2010; 5(2):124-51. PMID: 20429870; PMCID: PMC2935806.
  • 58. Dai T, Tegos GP, Zhiyentayev T, Mylonakis E, Hamblin MR. Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model. Lasers Surg Med. 2010; 42(1):38-44. PMID: 20077489; PMCID: PMC2820267.
  • 59. Huang L, Dai T, Hamblin MR. Antimicrobial photodynamic inactivation and photodynamic therapy for infections. Methods Mol Biol. 2010; 635:155-73. PMID: 20552347; PMCID: PMC2933785.
  • 60. Dai T, Huang YY, Hamblin MR. Photodynamic therapy for localized infections--state of the art. Photodiagnosis Photodyn Ther. 2009; 6(3-4):170-88. PMID: 19932449; PMCID: PMC2811240.
  • 61. Dai T, Tegos GP, Lu Z, Huang L, Zhiyentayev T, Franklin MJ, Baer DG, Hamblin MR. Photodynamic therapy for Acinetobacter baumannii burn infections in mice. Antimicrob Agents Chemother. 2009; 53(9):3929-34. PMID: 19564369; PMCID: PMC2737832.
  • 62. Dai T, Tegos GP, Burkatovskaya M, Castano AP, Hamblin MR. Chitosan acetate bandage as a topical antimicrobial dressing for infected burns. Antimicrob Agents Chemother. 2009; 53(2):393-400. PMID: 19015341; PMCID: PMC2630614.
  • 63. Dai T, Tegos GP, Rolz-Cruz G, Cumbie WE, Hamblin MR. Ultraviolet C inactivation of dermatophytes: implications for treatment of onychomycosis. Br J Dermatol. 2008; 158(6):1239-46. PMID: 18410410; PMCID: PMC2808700.
  • 64. Glaich AS, Goldberg LH, Dai T, Kunishige JH, Friedman PM. Fractional resurfacing: a new therapeutic modality for Becker's nevus. Arch Dermatol. 2007; 143(12):1488-90. PMID: 18086996.
  • 65. Castano AP, Dai T, Yaroslavsky I, Cohen R, Apruzzese WA, Smotrich MH, Hamblin MR. Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time. Lasers Surg Med. 2007; 39(6):543-50. PMID: 17659584; PMCID: PMC2935792.
  • 66. Glaich AS, Goldberg LH, Dai T, Friedman PM. Fractional photothermolysis for the treatment of telangiectatic matting: a case report. J Cosmet Laser Ther. 2007; 9(2):101-3. PMID: 17558760.
  • 67. Dai T, Yaseen MA, Diagaradjane P, Chang DW, Anvari B. Comparative study of cryogen spray cooling with R-134a and R-404a: implications for laser treatment of dark human skin. J Biomed Opt. 2006; 11(4):041116. PMID: 16965144.
  • 68. Behroozan DS, Goldberg LH, Dai T, Geronemus RG, Friedman PM. Fractional photothermolysis for the treatment of surgical scars: a case report. J Cosmet Laser Ther. 2006; 8(1):35-8. PMID: 16581684.
  • 69. Behroozan DS, Goldberg LH, Glaich AS, Dai T, Friedman PM. Fractional photothermolysis for treatment of poikiloderma of civatte. Dermatol Surg. 2006; 32(2):298-301. PMID: 16442059.
  • 70. Dai T, Diagaradjane P, Yaseen MA, Pikkula BM, Thomsen S, Anvari B. Laser-induced thermal injury to dermal blood vessels: analysis of wavelength (585 nm vs. 595 nm), cryogen spray cooling, and wound healing effects. Lasers Surg Med. 2005; 37(3):210-8. PMID: 16175632.
  • 71. Pikkula BM, Chang DW, Dai T, Anvari B. Epidermal and vascular damage analysis of in vivo human skin in response to 595 nm pulsed laser irradiation. Lasers Surg Med. 2005; 37(1):19-28. PMID: 15971245.
  • 72. Dai T, Pikkula BM, Wang LV, Anvari B. Comparison of human skin opto-thermal response to near-infrared and visible laser irradiations: a theoretical investigation. Phys Med Biol. 2004; 49(21):4861-77. PMID: 15584524.
  • 73. Dai T, Pikkula BM, Tunnell JW, Chang DW, Anvari B. Thermal response of human skin epidermis to 595-nm laser irradiation at high incident dosages and long pulse durations in conjunction with cryogen spray cooling: an ex-vivo study. Lasers Surg Med. 2003; 33(1):16-24. PMID: 12866117.
  • • Antimicrobial blue light inactivation of pathogenic microbes
  • • Light-based antimicrobial therapy for invasive fungal infections following combat-related injuries
  • • Antimicrobial blue light therapy for biofilm-associated infections
  • • A novel storage system for prolonging shelf life of human platelets
  • • Novel C70-fullerenes mediated oxygen-independent type-III photomechanism for inactivation of multidrug-resistant organisms