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  • 2006 B.S. Biochemistry and Cell Biology and Integrated Social and Cognitive Psychology, International University, Bremen, Germany
  • 2007 M.Sc. Molecular Biology, Jacobs University Bremen, Germany
  • 2010 Ph.D (with distinction) Cell Biology / Neuroscience, Jacobs University Bremen, Germany
  • 2010-2015 Postdoctoral Research Associate Neurobiology / Neuroregeneration, Northeastern University, Boston, MA
  • 2015-present Research Fellow Regenerative Medicine, Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), Boston, MA
Research investigations:
  1. Zupanc, G.K.H., Sîrbulescu, R.F., Nichols, A., Ilies, I., 2006. Electric interactions through chirping behavior in the weakly electric fish, Apteronotus leptorhynchus. Journal of Comparative Physiology A, 192, 159-173.
  2. Zupanc, G.K.H., Wellbrock, U.M., Sîrbulescu, R.F., Rajendran, R.S., 2009. Generation, long-term persistence, and neuronal differentiation of cells with nuclear aberrations in the adult zebrafish brain. Neuroscience, 159, 1338-1348.
  3. Sîrbulescu, R.F., Ilies, I., Zupanc, G.K.H., 2009. Structural and functional regeneration after spinal cord injury in the weakly electric teleost fish, Apteronotus leptorhynchus. Journal of Comparative Physiology A, 195, 699-714.
  4. Sîrbulescu, R.F., Zupanc, G.K.H., 2009. Dynamics of caspase-3-mediated apoptosis during spinal cord regeneration in the teleost fish, Apteronotus leptorhynchus. Brain Research, 1304, 14-25.
  5. Sîrbulescu, R.F., Zupanc, G.K.H., 2010. Effect of temperature on spinal cord regeneration in the weakly electric fish, Apteronotus leptorhynchus. Journal of Comparative Physiology A, 196, 359-368.
  6. Sîrbulescu, R.F., Zupanc, G.K.H., 2010. Inhibition of caspase-3-mediated apoptosis improves spinal cord repair in a regeneration-competent vertebrate system. Neuroscience, 171, 599-612.
  7. Sîrbulescu, R.F., Zupanc, G.K.H., 2011. Spinal cord repair in regeneration-competent vertebrates: adult teleost fish as a model system. Brain Research Reviews, 67, 73-93.
  8. Dauth, S.*, Sîrbulescu, R.F.*, Jordans, S., Rehders, M., Avena, L., Oswald, J., Lerchl, A., Saftig, P., Brix, K., 2011. Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits. BMC Neuroscience, 12:74. (* denotes equal contribution) [Highly Accessed]
  9. Zupanc, G.K.H., Sîrbulescu, R.F. 2011. Adult neurogenesis and neuronal regeneration in the central nervous system of teleost fish. European Journal of Neuroscience, 34, 917-929.
  10. Zupanc, G.K.H., Sîrbulescu, R.F., Ilies, I., 2012. Radial glia in the cerebellum of adult teleost fish: implications for the guidance of migrating new neurons. Neuroscience, 210, 416-430.
  11. Teles, M.C., Sîrbulescu, R.F., Wellbrock, U.M., Oliveira, R.F. & Zupanc, G.K.H., 2012. Adult neurogenesis in the brain of the Mozambique tilapia, Oreochromis mossambicus. Journal of Comparative Physiology A, 198, 427-449.
  12. Zupanc, G.K.H., Sîrbulescu, R.F. 2013. Teleost fish as a model system to study successful regeneration of the central nervous system. Current Topics in Microbiology and Immunology, 367, 193-233.
  13. Traniello, I.M.*, Sîrbulescu, R.F.*, Ilieş, I.*, Zupanc, G.K.H. 2014. Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: a novel teleost fish model of negligible senescence. Developmental Neurobiology, 74, 514-530. (* denotes equal contribution)
  14. Ilieş, I.*, Traniello, I.M.*, Sîrbulescu, R.F.*, Zupanc, G.K.H. 2014. Determination of relative age using growth increments of scales as a minimally invasive method in the tropical freshwater Apteronotus leptorhynchus. Journal of Fish Biology, 84, 1312-1325. (*denotes equal contributions)
  15. Zupanc, G.K.H., Ilieş, I., Sîrbulescu, R.F., Zupanc, M.M. 2014. Large-scale identification of proteins involved in the development of a sexually dimorphic behavior. Journal of Neurophysiology, 111, 1646-1654.
  16. Sîrbulescu, R.F., Ilieş, I., Zupanc, G.K.H. 2014. Quantitative analysis reveals dominance of gliogenesis over neurogenesis in an adult brainstem oscillator. Developmental Neurobiology, 74, 934-952. [Cover]
  17. Ilieş, I., Sîrbulescu, R.F., Zupanc, G.K.H. 2014. Indeterminate body growth and lack of gonadal decline in the brown ghost knifefish (Apteronotus leptorhynchus), an organism exhibiting negligible brain senescence. Canadian Journal of Zoology, 92, 947-953.
  18. Zupanc, G.K.H., Sîrbulescu, R.F. 2015. Cell replacement therapy: Lessons from teleost fish. Experimental Neurology, 263, 272-276.
  19. Sîrbulescu, R.F., Ilieş, I., Vitalo, A.G., Trull, K., Zhu, J., Traniello, I.M., Zupanc, G.K.H. 2015. Adult stem cells in the knifefish cerebellum. Developmental Neurobiology, 75, 39-65.
  20. Sîrbulescu, R.F., Ilieş, I., Zupanc, G.K.H. 2015. Matrix metalloproteinase-2 and -9 in the cerebellum of teleost fish: functional implications for adult neurogenesis. Molecular and Cellular Neuroscience, 68, 9-23.
  21. Salisbury, J.P., Sîrbulescu, R.F., Moran, B. M., Auclair, J.R., Zupanc, G.K.H., Agar, J.N. 2015. The central nervous system transcriptome of the weakly electric brown ghost knifefish (Apteronotus leptorhynchus): de novo assembly, annotation, and proteomics validation. BMC Genomics, 16:166. [Highly Accessed]
  22. Vitalo, A.G., Sîrbulescu, R.F., Ilies, I., Zupanc, G.K.H. 2016. Absence of gliosis in a teleost model of spinal cord regeneration. Journal of Comparative Physiology A, 202, 445-456.
Invited book chapter:
  1. Sîrbulescu, R.F., Zupanc, G.K.H., 2013. Neuronal regeneration. In Evans, D.H., Claiborne, J.B., Currie, S. (eds) The Physiology of Fishes, 4th edition. pp. 405-441. CRC Press, Boca Raton.
Conference proceedings:
  1. Hurst, L. A., Meissner, D., Sîrbulescu, R.F., Zupanc, G. K. H. (2005). Chirping in the weakly electric fish Apteronotus leptorhynchus: significance of conspecifics distance, angular orientation and chirps. 30th Göttingen Neurobiology Conference (6th meeting of the German Neuroscience Society), Göttingen, Germany.
  2. Zupanc, G.K.H., Sîrbulescu, R.F., Nichols, A., Ilies, I. (2007). Electric interactions through chirping behavior in the weakly electric fish, Apteronotus leptorhynchus. Proceedings of Electrosensory Systems: Satellite Meeting to the 8th International Congress of Neuroethology. Vancouver, Canada, July 21-22, 2007.
  3. Sîrbulescu, R.F., Jordans, S., Lerchl, A., Saftig, P., Kühl, N.M., Brix, K. (2007). Trafficking of cysteine cathepsins to the extracellular thyroid follicle lumen helps mice to improve their memory and learning skills. From single molecules to degradomics. Book of abstracts / Xth International Symposium on Proteinase Inhibitors and Biological Control, Portoroz, Slovenia, June 23-27, 2007; [editors Marko Dolinar, Veronika Stoka, Boris Turk, and Vito Turk]. Ljubljana: Jozef Stefan Institute, 2007, ISBN 978-961-6303-92-7:39.
Cover images:
  1. Sîrbulescu, R.F., Zupanc, G.K.H.: Cover image of January – June (1-6) issues of Volume 198 of the Journal of Comparative Physiology A (2012)
  2. Sîrbulescu, R.F., Zupanc, G.K.H.: Cover image of July – December (7-12) issues of Volume 200 of the Journal of Comparative Physiology A (2014)
  3. Sîrbulescu, R.F., Ilieş, I., Zupanc, G.K.H.: Cover image of September issue (9) of Volume 74 of Developmental Neurobiology (2014)
  • B cell Therapy for Wound Healing – Cellular and molecular mechanisms underlying B cell contribution to skin wound healing
  • Repurposing mesothelial cells for wound healing
Dr. Sîrbulescu has trained numerous students at Jacobs and Northeastern, and is committed to including dedicated undergraduate and graduate students as trainees and collaborators into research projects.
  • Antonia G. Vitalo, PhD candidate
  • Lisa Amelung, MS candidate (exchange student)
  • Kimberly König, BS candidate
  • Susan McQuade, BS candidate
  • Anja Mareike Neumann, BS candidate
  • Grace Severance, BS candidate
  • Ian M. Traniello, Research technician
  • Annette Müller, MS candidate (exchange student)
  • Krystal Trull, MS candidate
  • Jessica Henderson, BS candidate
  • Demetri Lemonias, BS candidate
  • Benjamin Moran, BS candidate
  • Jenny Zhu, BS candidate