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Application and utility of mass cytometry in vaccine development

Reeves PM, Sluder AE, Paul SR, Scholzen A, Kashiwagi S, Poznansky MC. FASEB J. 2017 Nov 1. pii: fj.201700325R. doi: 10.1096/fj.201700325R. [Epub ahead of print] Review.
PMID: 29092906

CXCR4 blockade with AMD3100 enhances Taxol chemotherapy to limit ovarian cancer cell growth

Reeves PM, Abbaslou MA, Kools FRW, Poznansky MC. Anticancer Drugs. 2017 Oct;28(9):935-942. doi: 10.1097/CAD.0000000000000518. PMID:28817386

Q-vaxcelerate: A distributed development approach for a new Coxiella burnetii vaccine.

Reeves PM, Paul SR, Sluder AE, Brauns TA, Poznansky MC. Hum Vaccin Immunother. 2017 Sep 21:0. doi: 10.1080/21645515.2017.1371377. [Epub ahead of print] PMID: 28933682

Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions.

Sîrbulescu RF, Boehm CK, Soon E, Wilks MQ, Ilieş I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin MD, El Fakhri G, Orgill DP, Sluder AE, Poznansky MC. Wound Repair Regen. 2017 Sep 18. doi: 10.1111/wrr.12584. [Epub ahead of print] PMID: 28922523

PD-1 expression in head and neck squamous cell carcinomas derives primarily from functionally anergic CD4+ TILs in the presence of PD-L1+ TAMs

Mattox A, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng Y, Chen H, Poznansky MC, Iyengar NM, Pai SI. Cancer Res. 2017 Sep 25. pii: canres.3453.2016. doi: 10.1158/0008-5472.CAN-16-3453. [Epub ahead of print] PMID: 28947422

Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine

Morse K, Kimizuka Y, Chan MPK, Shibata M, Shimaoka Y, Takeuchi S, Forbes B, Nirschl C, Li B, Zeng Y, Bronson RT, Katagiri W, Shigeta A, Sîrbulescu RF, Chen H, Tan RYY, Tsukada K, Brauns T, Gelfand J, Sluder A, Locascio JJ, Poznansky MC, Anandasabapathy N, Kashiwagi S. J Immunol. 2017 Aug 15;199(4):1319-1332. doi: 10.4049/jimmunol.1601873. Epub 2017 Jul 14. PMID: 28710250

Semiconductor diode laser device adjuvanting intradermal vaccine

Kimizuka Y, Callahan JJ, Huang Z, Morse K, Katagiri W, Shigeta A, Bronson R, Takeuchi S, Shimaoka Y, Chan MP, Zeng Y, Li B, Chen H, Tan RY, Dwyer C, Mulley T, Leblanc P, Goudie C, Gelfand J, Tsukada K, Brauns T, Poznansky MC, Bean D, Kashiwagi S. Vaccine. 2017 Apr 25;35(18):2404-2412. doi: 10.1016/j.vaccine.2017.03.036. Epub 2017 Mar 30. PMID: 28365253

HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus.

Fusco DN, Pratt H, Kandilas S, Cheon SS, Lin W, Cronkite DA, Basavappa M, Jeffrey KL, Anselmo A, Sadreyev R, Yapp C, Shi X, O’Sullivan JF, Gerszten RE, Tomaru T, Yoshino S, Satoh T, Chung RT.
Front Microbiol. 2017 Feb 20;8:240. doi: 10.3389/fmicb.2017.00240. eCollection 2017. PMID: 28265266

Biomechanically primed liver microtumor array as a high-throughput mechanopharmacological screening platform for stroma-reprogrammed combinatorial therapy.

Zhu L, Fan X, Wang B, Liu L, Yan X, Zhou L, Zeng Y, Poznansky MC, Wang L, Chen H, Du Y. Biomaterials. 2017 Apr;124:12-24. doi: 10.1016/j.biomaterials.2017.01.030.

Classification of Laser Vaccine Adjuvants.

Kashiwagi S, Brauns T, Poznansky MC. J Vaccines Vaccin. 2016 Feb;7(1). pii: 307.

Improved Antitumoral Efficacy of Mesothelin Targeted Immune Activating Fusion Protein in Murine Model of Ovarian Cancer

Yang Zeng, Binghao Li, Patrick Reeves, Chongzhao Ran, Zhao Liu, Mojgan Agha-Abbaslou, Jianping Yuan, Pierre Leblanc, Ann Sluder, Jeffrey Gelfand, Timothy Brauns, Mark Poznansky and Huabiao Chen. Int J Cancer Clin Res. 2016, 3: 051

A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice.

Sayeed MA, Bufano MK, Xu P, Eckhoff G, Charles RC, Alam MM, Sultana T, Rashu MR, Berger A, Gonzalez-Escobedo G, Mandlik A, Bhuiyan TR, Leung DT, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Vann WF, Kováč P, Ryan ET.
PLoS Negl Trop Dis. 2015 Jul 8;9(7):e0003881. doi: 10.1371/journal.pntd.0003881. eCollection 2015 Jul.

Alginate Encapsulant Incorporating CXCL12 Supports Long‐Term Allo‐and Xenoislet Transplantation Without Systemic Immune Suppression

Chen T, Yuan J, Duncanson S, Hibert ML, Kodish BC, Mylavaganam G, Maker M, Li H, Sremac M, Santuosso M, Forbes B, Kashiwagi S, Cao J, Lei J, Thomas M, Hartono C, Sachs D, Markmann J, Sambanis A, Poznansky MC. Amer J Transplant 2015;15:618-627.

Could mycobacterial Hsp70-containing fusion protein lead the way to an affordable therapeutic cancer vaccine?

Brauns T, Leblanc P, Gelfand JA, Poznanski M.
Expert Rev Vaccines. 2015 Mar;14(3):435-46. doi: 10.1586/14760584.2015.979797. Epub 2014 Dec 13. Review.

Laser vaccine adjuvants: History, progress, and potential

Kashiwagi S, Brauns T, Gelfand J, Poznansky MC. Hum Vaccin Immunother 2014;10(7):1892-907.

A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma

Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC. A novel mycobacterial. J Hematol Oncol 2014 Feb 24;7:15.

Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide

Alam MM, Bufano MK, Xu P, Kalsy A, Yu Y, Freeman YW, Sultana T, Rashu MR, Desai I, Eckhoff G, Leung DT, Charles RC, LaRocque RC, Harris JB, Clements JD, Calderwood SB, Qadri F, Vann WF, Kováč P, Ryan ET. PLoS Negl Trop Dis. 2014 Feb 6;8(2):e2683. doi: 10.1371/journal.pntd.0002683. eCollection 2014 Feb.

VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever.

Leblanc P, Moise L, Luza C, Chantaralawan K, Lezeau L, Yuan J, Field M, Richer D, Boyle C, Martin WD, Fishman JB, Berg EA, Baker D, Zeigler B, Mais DE, Taylor W, Coleman R, Warren HS, Gelfand JA, De Groot AS, Brauns T, Poznansky MC. Hum Vaccin Immunother. 2014;10(10):3022-38. doi: 10.4161/hv.34413. Review.

Near-infrared laser adjuvant for influenza vaccine

Kashiwagi S, Yuan J, Forbes B, Hibert ML, Lee EL, Whicher L, Goudie C, Yang Y, Chen T, Edelblute B, Collette B, Edington L, Trussler J, Nezivar J, Leblanc P, Tsukada P, Suematsu M, Dover J, Brauns T, Gelfand J, and Poznansky MC. PLoS One 2013 Dec 11;8(12):e82899.

Near-infrared laser adjuvant for influenza vaccine.

Kashiwagi S, Yuan J, Forbes B, Hibert ML, Lee EL, Whicher L, Goudie C, Yang Y, Chen T, Edelblute B, Collette B, Edington L, Trussler J, Nezivar J, Leblanc P, Bronson R, Tsukada K, Suematsu M, Dover J, Brauns T, Gelfand J, Poznansky MC. PLoS One. 2013 Dec 11;8(12):e82899. doi: 10.1371/journal.pone.0082899.