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Laboratory Profile
  1. Characterization and development of a novel vaccine for Q-fever (Coxiella Burnetti)
  2. Development of a tailored, rapidly devlierable, and cost-effective vaccine to promote anti-tumor immunity.
  3. Study of tumor cell biology to better implement small molecules that modulate tumor adaptation and escape strategies.
  • Principal investigator: Patrick Reeves, PhD
  • Ottavia Clemente, PhD Candidate
  • Sherry Xiaoyun Tong, MD
  • Yan Wang, MD
  • Xavier Catena, MS
  • Mathieu von Joest, MS
  • Arya Sharifzadeh, MS
  • Jing Zeng, MS
  • Lisanne Schoutens (Cambridge University)
  • Carl Pierce (University of Massachusettes)
  • Samantha Wong (Imperial College)
  • Jay Kritchai Vutipongsatorn (Imperial College)
  • Anita Vohra, (Connecticut University)
  • Ellie Dunstone, (Cambridge University)
  • Mojgan Abbaslou, MD; Susan Raju-Paul, MD
  • Farah Kools
  • Reem Omer, (Harvard University)
  1. Reeves PM, Bommarius B, Lebeis S, McNulty S, Christensen J, Swimm A, Chahroudi A, Chavan R, Feinberg MB, Veach D, Bornmann W, Sherman M, Kalman D. Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases. Nat Med. 2005 Jul;11(7):731-9.
  2. Swimm A, Bommarius B, Reeves P, Sherman M, Kalman D. Complex kinase requirements for EPEC pedestal formation. Nat Cell Biol. 2004 Sep;6(9):795; author reply 795-6
  3. Swimm A, Bommarius B, Li Y, Cheng D, Reeves P, Sherman M, Veach D, Bornmann W, Kalman D. Enteropathogenic Escherichia coli use redundant tyrosine kinases to form actin pedestals. Mol Biol Cell. 2004 Aug;15(8):3520-9
  4. Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves PM, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells. Cell Stem Cell 2012 Aug 3
  5. Hagemann AI, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S. In-vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos. J Cell Sci. 2014 Jul 29
  6. Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. J Hematol Oncol. 2014 Feb 24;7:15.
  7. Reeves PM, Abbaslou MA, Kools FRW, Poznansky MC. CXCR4 blockade with AMD3100 enhances Taxol chemotherapy to limit ovarian cancer cell growth. Anticancer Drugs. 2017 Aug 16. doi: 10.1097/CAD.0000000000000518. [Epub ahead of print]
Patent
Kalman D, Bornmann WG, Reeves PM, Swimm, AI. Compositions and methods of use for tyrosine kinase inhibitors to treat pathogenic infection, US8,765,777; issued 12/16/2010
  • Sarina Gupta