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Laboratory Profile
  1. Immunotherapy for Malignant Mesothelioma that Combines CXCL12/CXCR4 Blockade with a Mesothelin-Targeted Fusion Protein
  2. Immunotherapy for Mesothelioma and Ovarian Caner with an in vivo DC Vaccine and PD-1/PD-L1 Blockade
  3. Injectable Extracellular Matrix-Derivative Micro-Scaffolds (iEMS) mouse tumor model in drug evaluation and cancer immunotherapy
  4. Profiling the Immune Contexture in Human Cancers and Infectious Diseases
  • Principal investigator: Huabiao Chen, MD, PhD
  • Postdoctoral Research Fellows: Yang (Claire) Zeng, MD, PhD ; Xiying Qu, PhD
  • Research Scientist:
  • Peter Rees, BA candidate
  • Zhao Liu, MD, PhD
  • Alice Tang, Imperial College
  • Binghao Li, MD candidate
  • Qiuyan Liu, MD, PhD; Yingying Liang, MSc
  1. Lu Zhu, Xingliang Fan, Bingjie Wang, Longwei Liu, Xiaojun Yan, Lyu Zhou, Yang Zeng, Mark C. Poznansky, Lili Wang, Huabiao Chen, Yanan Du. Biomechanically primed liver microtumor array as a high-throughput mechanopharmacological screening platform for stroma-reprogrammed combinatorial therapy. Biomaterials. http://dx.doi.org/10.1016/j.biomaterials.2017.01.030
  2. Flerin NC, Chen H, Glover TD, Lamothe PA, Zheng JH, Fang JW, Ndhlovu ZM, Newell EW, Davis MM, Walker BD, Goldstein H. TCR Clonotype-specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T Cell Clones is Not Mediated by TCR Alone. J Virol. 2017 Jan 11. pii: JVI.02412-16. doi: 10.1128/JVI.02412-16.
  3. Yang Zeng, Binghao Li, Patrick Reeves, Chongzhao Ran, Zhao Liu, Mojgan Agha-Abbaslou, Jianping Yuan, Pierre Leblanc, Ann Sluder, Jeffrey Gelfand, Timothy Brauns, Mark Poznansky, Huabiao Chen*. Improved antitumoral efficacy of mesothelin targeted immune activating fusion protein in murine model of ovarian cancer. Int J Cancer Clin Res. 2016, 3: 051
  4. Chunfu Zhang, Kui Liu, Tao Li, Jie Fang, Yanling Ding, Lingxian Sun, Tao Tu, Xinyi Jiang, Shanmei Du, Jiabo Hu, Wei Zhu, Huabiao Chen*, and Xiaochun Sun*. miR-21: A gene of dual regulation in breast cancer. Int J Oncol. 2015 Nov 5. doi: 10.3892/ijo.2015.3232. [Epub ahead of print].
  5. Ndhlovu ZM, Stampouloglou E, Cesa K, Mavrothalassitis O, Alvino DM, Li JZ, Wilton S, Karel D, Piechocka-Trocha A, Chen H, Pereyra F, Walker BD. The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers. J Virol. 2015 Nov 1;89(21):10735-47. doi: 10.1128/JVI.01527-15. Epub 2015 Aug 12.
  6. Tao Li, Chunfu Zhang, Yanling Ding, Wei Zhai, Kui Liu, Fan Bo, Tao Tu, Lingxian Sun, Wei Zhu, Fangfang Zhou, Wenkai Qi, Jiabo Hu, Huabiao Chen*, and Xiaochun Sun*. Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in breast cancer cells MCF-7 and MDA-MB-231 through activation of the ERK pathway. Oncol Rep 2015; 34: 1469-1477.
  7. Kui Liu, Chunfu Zhang, Tao Li, Yanling Ding, Tao Tu, Fangfang Zhou, Wenkai Qi, Huabiao Chen* and Xiaochun Sun*. Let-7a inhibits growth and migration of breast cancer cells by targeting HMGA1. Int J Oncol 2015;DOI:10.3892/ijo.2015.2949.
  8. Dongfang Liu, Huabiao Chen*. Structured Illumination Microscopy Improves Visualization of Lytic Granules in HIV-1 Specific CTL Immunological Synapses. AIDS Res Hum Retroviruses 2015 Apr 1. [Epub ahead of print].
  9. Wang P, Qu X, Wang X, Zhu X, Zeng H, Chen H, Zhu H. Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5'-LTR promoter. Gene Ther. 2014;21:490-495.
  10. Zhu X, Liu S, Wang P, Qu X, Wang X, Zeng H, Chen H, Zhu H. Oxaliplatin antagonizes HIV-1 latency by activating NF-κB without causing global T cell activation. Biochem Biophys Res Commun. 2014;450:202-207.
  11. Maria H. Foley, Talitha Forcier, Elizabeth McAndrew, Michael Gonzalez, Huabiao Chen, Boris Juelg, Bruce D. Walker, and Darrell J. Irvine. High Avidity CD8(+) T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function. Plos One 2014;9:e87873.
  12. Jianping Yuan, Satoshi Kashiwagi, Jean Nezivar, Yuan Yang, Mai Nguyen, Huabiao Chen, Sandra Orsulic, Nathalie Scholler, Glenn Dranoff, Timothy Brauns, Jeffrey Gelfand, Pierre Leblanc and Mark C. Poznansky. A Mycobacterial Hsp70 Fusion Protein Targeting Mesothelin Augments Antitumor Immunity and Prolongs Survival in Murine Models of Ovarian Cancer and Mesothelioma. J Hematol Oncol 2014;7:15-24.
  13. Zhen Xia, Huabiao Chen, Seung-gu Kang, Tien Huynh, Justin W. Fang, Pedro A. Lamothe, Bruce D. Walker, and Ruhong Zhou. The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function. Sci Rep 2013; 4:4087.
  14. Huabiao Chen, Zaza M. Ndhlovu, Dongfang Liu, Lindsay C. Porter, Sam Darko, Justin W. Fang, Mark A. Brockman, Toshiyuki Miura, Zabrina L. Brumme, Arne Schneidewind, Alicja Piechocka-Trocha, Kevin T. Cesa, Jennifer Sela, Thai D. Cung, Ildiko Toth, Florencia Pereyra, Xu G. Yu, Daniel C. Douek, Daniel E. Kaufmann, Todd M. Allen, Bruce D. Walker. TCR clonotypes modulates the protective effect of HLA class I molecules in HIV-1-infection. Nat Immunol 2012;13:691-700.
  15. Zhang SC, Martin E, Shimada M, Godfrey SB, Fricke J, Locastro S, Lai NY, Liebesny P, Carlson JM, Brumme CJ, Ogbechie OA, Chen H, Walker BD, Brumme ZL, Kavanagh DG, Le Gall S. Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals. J Immunol 2012;188(12):5924-5934.
  16. Huabiao Chen, Chun Li, Jinghe Huang, Thai Cung, Jill Beamon, Katie Seiss, Mary Carrington, Lindsay C. Porter, Patrick Burke, Yue Yang, Bethany Ryan, Ruiwu Liu, Robert Weiss, Florencia Pereyra, William Cress, Abraham L. Brass, Eric S. Rosenberg, Bruce D. Walker, Xu G. Yu, Mathias Lichterfeld. CD4 T cells from elite controllers resist HIV-1 infection by selective upregulation of p21 (cip-1/waf-1). J Clin Invest 2011;121:1549-1560.
  17. Navin Varadarajan, Boris Julg, Yvonne Yamanaka, Huabiao Chen, Adebola Ogunniyi, Elizabeth McAndrew, Lindsay Porter, Alicja Piechocka-Trocha, Brenna Hill, Daniel Douek, Florencia Pereyra, Bruce D. Walker, J. Christopher Love. A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis. J Clin Invest, 2011;121:4322-4331.
  18. Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, Bruce D. Walker. Differential neutralization of HIV replication in autologous CD4 T cells by HIV-specific CTL. J Virol 2009;83:3138-3149.
  19. Jianping Yuan, Ping Li, Jing Tao, Xiaodong Shi, Baoyu Hu, Huabiao Chen and Xiaokui Guo. H. pylori escape host immunoreaction through inhibiting ILK expression by VacA. Cell Mol Immunol 2009; 6:191-197.
  20. Arne Schneidewind, Mark A. Brockman, John Sidney, Yaoyu E. Wang, Huabiao Chen, Todd J. Suscovich, Bin Li, Rahma I. Adam, Rachel L. Allgaier, Bianca R. Mothé, Thomas Kuntzen, Cesar Oniangue-Ndza, Alicja Trocha, Xu G. Yu, Christian Brander, Alessandro Sette, Bruce D. Walker, and Todd M. Allen. Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. J Virol 2008: 82:5594-605.
  21. Huabiao Chen, Jinlin Hou, Xiaodong Jiang, Shiwu Ma, Minjie Meng, Baomei Wang, Minghui Zhang, Mingxia Zhang, Xiaoping Tang, Fuchun Zhang, Tao Wan, Nan Li, Yizhi Yu, Hongbo Hu, Ruifu Yang, Wei He, Xiaoning Wang and Xuetao Cao. Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals. J Immunol 2005;175:591-598.
  22. Baomei Wang, Huabiao Chen, Xiaodong Jiang, Minghui Zhang, Tao Wang, Nan Li, Xiangyang Zhou, yanfeng Wu, Feng Yang, Yizhi Yu, Xiaoning Wang, Ruifu Yang and Xuetao Cao. Identification of an HLA-A*0201-restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein. Blood 2004;104:200-206.
  23. Jianping Yuan, Tao Li, Huabiao Chen, Zhenhong Li, Guizhen Yang, Baoyu Hu, Xiaoding Shi, Shanqing Tong, Yixue Li and Xiaokui Guo. Analysis of gene expression profile in gastric cancer cells stimulated with Helicobacter pylori isogenic strains. J Med Microbiol 2004;53:965-974.
  24. Qiuyan Liu, Taoying Chen, Huabiao Chen, Minghui Zhang, Nan Li, Zhanjun Lu, Pengcheng Ma and Xuetao Cao. Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation. Biochem Biophys Res Commun 2004;319:980-986.
  25. Huabiao Chen*, Dexing Fang, Faqing Li, Huiying Jin, Weiguo Tan and Suqin Li. A novel hepatitis B virus mutant with A-to-G at nt551 in the surface antigen gene. World J Gastroenterol 2003;9:304-308.