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CHEN LAB

Mission Statement:

To investigate immunopathogenesis of cancer and HIV/AIDS and develop vaccines and immunotherapies against these diseases.

Research Focus:

The Chen Laboratory focuses on developing novel molecule-based and cell-based immunotherapies for treatment of various cancers and understanding mechanism(s) by which HIV infection promotes the development or progression of tumors.

VIC Projects List

  • Novel immunotherapies for mesothelin-expressing cancers that combine a mesothelin-targeted immune-activating fusion protein with blockade of PD-1/PD-L1 or CXCR4/CXCL12 pathway
  • New subsets of mesenchymal stem cells (MSCs) and its derived extracellular vesicles/exosomes for treatment of various cancers
  • Regulatory B cells (Breg) in the development of AIDS-related tumors

Highlighted Publications

Oncotarget. 2019 Jul 8;10(43):4479-4491. Zeng Y, Li B, Li T, Liu W, Ran C, Penson RT, Poznansky MC, Du Y, Chen H.

FASEB J. 2019 May;33(5):6596-6608 Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC.

Int J Oncol. 2019 May;54(5):1843-1852 Zhou X, Li T, Chen Y, Zhang N, Wang P, Liang Y, Long M, Liu H, Mao J, Liu Q, Sun X, Chen H.

Cancer Immunol Res. 2018 May;6(5):539-551 Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC.

Cancer Res. 2018 Jul 15;78(14):3938-3953 Li B, Wang Z, Wu H, Xue M, Lin P, Wang S, Lin N, Huang X, Pan W, Liu M, Yan X, Qu H, Sun L, Li H, Wu Y, Teng W, Wang Z, Zhou X, Chen H, Poznansky MC, Ye Z.

Oncotarget. 2018 Jan 2;9(1):591-606  Li T, Zhang J, Zhang J, Zhang N, Zeng Y, Tang S, Tao Z, Qu X, Jia J, Zhu W, Sun X, Chen H.

Nat Immunol. 2012 Jun 10;13(7):691-700 Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BD.

J Clin Invest. 2011 Apr;121(4):1549-60 Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M.

RESEARCH TEAM

Huabiao Chen, PhD

Principal Investigator

Tao Li, BS

Joint PhD candidate, Jiangsu University, China

Wanghao Chen, MS

Joint PhD candidate, Southeast University, China

Lu Wan, MA

Surgery Joint PhD candidate, Xiangya Hospital, China

Sen Han, BS

Joint PhD candidate, Yangzhou University, China

Ying Huang, MD

Research Fellow

 

 

2015-2017 Binghao Li, MBBS. Physician at the Second Affiliated Hospital of Zhejiang University, China

2015 Peter Rees. Graduate student at Cambridge University, UK

2015-2017 Yang Zeng PhD. Research Fellow at DFCI, Boston

2017-2018 Xiying Qu, PhD. Instructor at MGH, Boston

2016 Alice Tang. Graduate student at Imperial College, UK

2016-2017 Qiuyan Liu, MD, PhD. Professor at the Second Military Medical University, China

2016-2017 Yingying Liang, MA. PhD candidate at University of Rochester, NY

2017 Reyna Niner. MD candidate at Tufts University, Boston

2018-2019 Xiang Li. Graduate student at Hongkong University, China

ALUMNI